PCNA-binding proteins in the archaea: novel functionality beyond the conserved core.
Curr Genet
; 62(3): 527-32, 2016 Aug.
Article
en En
| MEDLINE
| ID: mdl-26886233
Sliding clamps play an essential role in coordinating protein activity in DNA metabolism in all three domains of life. In eukaryotes and archaea, the sliding clamp is PCNA (proliferating cell nuclear antigen). Across the diversity of the archaea PCNA interacts with a highly conserved set of proteins with key roles in DNA replication and repair, including DNA polymerases B and D, replication factor C, the Fen1 nuclease and RNAseH2, but this core set of factors is likely to represent a fraction of the PCNA interactome only. Here, I review three recently characterised non-core archaeal PCNA-binding proteins NusS, NreA/NreB and TIP, highlighting what is known of their interactions with PCNA and their functions in vivo and in vitro. Gaining a detailed understanding of the non-core PCNA interactome will provide significant insights into key aspects of chromosome biology in divergent archaeal lineages.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Archaea
/
Antígeno Nuclear de Célula en Proliferación
Idioma:
En
Revista:
Curr Genet
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Estados Unidos