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Genetic Background of Immune Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children.
Skoczen, Szymon; Bik-Multanowski, Miroslaw; Pietrzyk, Jacek J; Grabowska, Agnieszka; Fijorek, Kamil; Strojny, Wojciech; Klus-Kwiecinska, Kinga; Balwierz, Walentyna; Siedlar, Maciej.
Afiliación
  • Skoczen S; Department of Clinical Immunology, Chair of Clinical Immunology and Transplantation, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka Street 265, 30-663 Krakow, Poland.
  • Bik-Multanowski M; Department of Medical Genetics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Pietrzyk JJ; Department of Medical Genetics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Grabowska A; Department of Medical Genetics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Fijorek K; Department of Statistics, Cracow University of Economics, Rakowicka Street 27, 31-510 Krakow, Poland.
  • Strojny W; Department of Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Klus-Kwiecinska K; Department of Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Balwierz W; Department of Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
  • Siedlar M; Department of Clinical Immunology, Chair of Clinical Immunology and Transplantation, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka Street 265, 30-663 Krakow, Poland.
Stem Cells Int ; 2016: 2626081, 2016.
Article en En | MEDLINE | ID: mdl-26880945
Immune reactions are among the most serious complications observed after hematopoietic stem cell transplantation (HSCT) in children. Microarray technique allows for simultaneous assessment of expression of nearly all human genes. The objective of the study was to compare the whole genome expression in children before and after HSCT. A total of 33 children referred for HSCT were enrolled in the study. In 70% of the patients HSCT was performed for the treatment of neoplasms. Blood samples were obtained before HSCT and six months after the procedure. Subsequently, the whole genome expression was assessed in leukocytes using GeneChip Human Gene 1.0 ST microarray. The analysis of genomic profiles before and after HSCT revealed altered expression of 124 genes. Pathway enrichment analysis revealed upregulation of five pathways after HSCT: allograft rejection, graft-versus-host disease, type I diabetes mellitus, autoimmune thyroid disease, and viral myocarditis. The activation of those pathways seems to be related to immune reactions commonly observed after HSCT. Our results contribute to better understanding of the genomic background of the immunologic complications of HSCT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Stem Cells Int Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Stem Cells Int Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos