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The efficacy of a sulphated polysaccharide fraction from Hypnea musciformis against diarrhea in rodents.
Sousa, Nayara A; Barros, Francisco Clark N; Araújo, Thiago S L; Costa, Douglas S; Souza, Luan Kelves M; Sousa, Francisca Beatriz M; Leódido, Ana Carolina M; Pacífico, Dvison M; de Araújo, Simone; Bezerra, Francisco F; Freitas, Ana Lúcia P; Medeiros, Jand Venes R.
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  • Sousa NA; Biotechnology and Biodiversity Center Research, BIOTEC, Post-graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, Piauí, Brazil.
  • Barros FC; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil; Federal Institute of Education, Science and Technology of Ceará, Juazeiro do Norte, Ceará, Brazil.
  • Araújo TS; Biotechnology and Biodiversity Center Research, BIOTEC, Post-graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, Piauí, Brazil.
  • Costa DS; Medicinal Plant Research Center, NPPM, Post-graduation Program in Pharmacology, Federal University of Piauí, Teresina, Piauí, Brazil.
  • Souza LK; Post-graduation Program in Biomedical Sciences, Federal University of Piauí, Parnaíba, Piauí, Brazil.
  • Sousa FB; Biotechnology and Biodiversity Center Research, BIOTEC, Post-graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, Piauí, Brazil.
  • Leódido AC; Biotechnology and Biodiversity Center Research, BIOTEC, Post-graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, Piauí, Brazil.
  • Pacífico DM; Biotechnology and Biodiversity Center Research, BIOTEC, Post-graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, Piauí, Brazil.
  • de Araújo S; Biotechnology and Biodiversity Center Research, BIOTEC, Post-graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, Piauí, Brazil.
  • Bezerra FF; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Freitas AL; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Medeiros JV; Biotechnology and Biodiversity Center Research, BIOTEC, Post-graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, Piauí, Brazil; Medicinal Plant Research Center, NPPM, Post-graduation Program in Pharmacology, Federal University of Piauí, Teresina, Piauí, Brazil; Post-graduatio
Int J Biol Macromol ; 86: 865-75, 2016 May.
Article en En | MEDLINE | ID: mdl-26879913
Seaweeds are sources of diverse bioactive compounds, such as sulphated polysaccharides. This study was designed to evaluate the chemical composition and anti-diarrheal activity of a fraction of sulphated polysaccharide (PLS) obtained from the red seaweed Hypnea musciformis in different animal models, and to elucidate the underlying mechanisms. PLS was obtained by aqueous extraction, with a yield of 31.8% of the seaweed dry weight. The total carbohydrate content accounted for 99% of the sample. The sulfate content of the polysaccharide was 5.08% and the percentage of carbon was 25.98%. Pretreatment with all doses of PLS inhibited castor oil-induced diarrhea, with reduction of the total amount of stool, diarrheal stools, and the severity of diarrhea. PLS (90 mg/Kg) decreased castor oil- and PGE2-induced enteropooling. In addition, PLS (90 mg/Kg) increased the Na(+)/K(+)-ATPase activity in the small intestine and reduced gastrointestinal transit, possibly via activation of cholinergic receptors. Interestingly, the cholera toxin-induced fluid secretion and Cl(-) ion levels decreased in the intestinal contents of the animals pretreated with PLS (90 mg/kg), probably via reduction of toxin-GM1 receptor binding. In conclusion, PLS exerts anti-diarrheal activity by increasing Na(+)/K(+)-ATPase activity, inhibiting gastrointestinal motility, and blocking the toxin-GM1 receptor binding.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Sulfatos / Diarrea / Rhodophyta Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Sulfatos / Diarrea / Rhodophyta Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos