X-ray fiber diffraction analysis shows dynamic changes in axial tubulin repeats in native microtubules depending on paclitaxel content, temperature and GTP-hydrolysis.

Kamimura, Shinji; Fujita, Yosuke; Wada, Yuuko; Yagi, Toshiki; Iwamoto, Hiroyuki

Kamimura, Shinji; Fujita, Yosuke; Wada, Yuuko; Yagi, Toshiki; Iwamoto, Hiroyuki.

Afiliación

Kamimura S; Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, Kasuga, Bunkyo, Tokyo, Japan.
Fujita Y; Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, Kasuga, Bunkyo, Tokyo, Japan.
Wada Y; Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, Kasuga, Bunkyo, Tokyo, Japan.
Yagi T; Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Hiroshima, Japan.
Iwamoto H; Life and Environmental Division, SPring-8, Japan Synchrotron Radiation Research Institute (JASRI), Sayo, Hyogo, Japan.

Cytoskeleton (Hoboken) ; 73(3): 131-44, 2016 Mar.

Article en En | MEDLINE | ID: mdl-26873786

Asunto(s)

Guanosina Trifosfato/química; Microtúbulos/química; Microtúbulos/ultraestructura; Paclitaxel/química; Tubulina (Proteína)/química; Animales; Hidrólisis; Porcinos; Tubulina (Proteína)/metabolismo; Difracción de Rayos X

Palabras clave

GMPCPP; X-ray fiber diffraction analysis; microtubule structure in solution; negative thermal expansion of microtubules; paclitaxel; shear-flow alignment of microtubules

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Paclitaxel / Guanosina Trifosfato / Microtúbulos Límite: Animals Idioma: En Revista: Cytoskeleton (Hoboken) Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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