Your browser doesn't support javascript.
loading
Value of Magnetic Resonance Imaging Without or With Applicator in Place for Target Definition in Cervix Cancer Brachytherapy.
Pötter, Richard; Federico, Mario; Sturdza, Alina; Fotina, Irina; Hegazy, Neamat; Schmid, Maximilian; Kirisits, Christian; Nesvacil, Nicole.
Afiliación
  • Pötter R; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.
  • Federico M; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Radiation Oncology, Gran Canaria University Hospital, Las Palmas de Gran Canaria, Spain.
  • Sturdza A; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
  • Fotina I; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Institute of Physics and Technology, Tomsk Polytechnic University, Tomsk Oblast, Russia.
  • Hegazy N; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Clinical Oncology, Medical University of Alexandria, Alexandria, Egypt.
  • Schmid M; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.
  • Kirisits C; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.
  • Nesvacil N; Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria. Electronic address: nicole.nesvacil@meduniwien.ac.at.
Int J Radiat Oncol Biol Phys ; 94(3): 588-97, 2016 Mar 01.
Article en En | MEDLINE | ID: mdl-26867887
PURPOSE: To define, in the setting of cervical cancer, to what extent information from additional pretreatment magnetic resonance imaging (MRI) without the brachytherapy applicator improves conformity of CT-based high-risk clinical target volume (CTVHR) contours, compared with the MRI for various tumor stages (International Federation of Gynecology and Obstetrics [FIGO] stages I-IVA). METHODS AND MATERIALS: The CTVHR was contoured in 39 patients with cervical cancer (FIGO stages I-IVA) (1) on CT images based on clinical information (CTVHR-CTClinical) alone; and (2) using an additional MRI before brachytherapy, without the applicator (CTVHR-CTpre-BT MRI). The CT contours were compared with reference contours on MRI with the applicator in place (CTVHR-MRIref). Width, height, thickness, volumes, and topography were analyzed. RESULTS: The CT-MRIref differences hardly varied in stage I tumors (n=8). In limited-volume stage IIB and IIIB tumors (n=19), CTVHR-CTpre-BT MRI-MRIref volume differences (2.6 cm(3) [IIB], 7.3 cm(3) [IIIB]) were superior to CTVHR-CTClinical-MRIref (11.8 cm(3) [IIB], 22.9 cm(3) [IIIB]), owing to significant improvement of height and width (P<.05). In advanced disease (n=12), improved agreement with MR volume, width, and height was achieved for CTVHR-CTpre-BT MRI. In 5 of 12 cases, MRIref contours were partly missed on CT. CONCLUSIONS: Pre-BT MRI helps to define CTVHR before BT implantation appropriately, if only CT images with the applicator in place are available for BT planning. Significant improvement is achievable in limited-volume stage IIB and IIIB tumors. In more advanced disease (extensive IIB to IVA), improvement of conformity is possible but may be associated with geographic misses. Limited impact on precision of CTVHR-CT is expected in stage IB tumors.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiterapia / Imagen por Resonancia Magnética / Carcinoma de Células Escamosas / Neoplasias del Cuello Uterino Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Int J Radiat Oncol Biol Phys Año: 2016 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiterapia / Imagen por Resonancia Magnética / Carcinoma de Células Escamosas / Neoplasias del Cuello Uterino Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Int J Radiat Oncol Biol Phys Año: 2016 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos