Development and pre-validation of an in vitro transactivation assay for detection of (anti)androgenic potential compounds using 22Rv1/MMTV cells.

Sun, Seunghan; Park, Eun-Jung; Choi, Yun-Ho; Lee, Hee-Seok; Ahn, Byung Yoon; Dong, Mi-Sook

Sun, Seunghan; Park, Eun-Jung; Choi, Yun-Ho; Lee, Hee-Seok; Ahn, Byung Yoon; Dong, Mi-Sook.

Afiliación

Sun S; School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
Park EJ; Food Safety Risk Assessment Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do 363-700, Republic of Korea.
Choi YH; School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
Lee HS; Food Safety Risk Assessment Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do 363-700, Republic of Korea.
Ahn BY; School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
Dong MS; School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea. Electronic address: msdong@korea.ac.kr.

Reprod Toxicol ; 60: 156-66, 2016 04.

Article en En | MEDLINE | ID: mdl-26867867

Asunto(s)

Antagonistas de Andrógenos/farmacología; Andrógenos/farmacología; Receptores Androgénicos/genética; Activación Transcripcional/efectos de los fármacos; Bioensayo; Línea Celular Tumoral; Genes Reporteros; Humanos; Luciferasas/metabolismo

Palabras clave

22Rv1/MMTV cell line; Androgen receptor-mediated transcriptional activation assay; Androgenic and anti-androgenic endocrine disruptors; Endocrine disruptor screening

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Androgénicos / Activación Transcripcional / Antagonistas de Andrógenos / Andrógenos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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