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Childhood obesity-related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements.
Bruyndonckx, Luc; Hoymans, Vicky Y; Lemmens, Katrien; Ramet, José; Vrints, Christiaan J.
Afiliación
  • Bruyndonckx L; Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, University Hospital Antwerp, Edegem, Belgium.
  • Hoymans VY; Department of Pediatrics, University Hospital Antwerp, Edegem, Belgium.
  • Lemmens K; Cardiovascular Diseases, Department of Translational Pathophysiological Research, University of Antwerp, Antwerp, Belgium.
  • Ramet J; Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
  • Vrints CJ; Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, University Hospital Antwerp, Edegem, Belgium.
Pediatr Res ; 79(6): 831-7, 2016 06.
Article en En | MEDLINE | ID: mdl-26866906
Childhood obesity jeopardizes a healthy future for our society's children as it is associated with increased cardiovascular morbidity and mortality later on in life. Endothelial dysfunction, the first step in the development of atherosclerosis, is already present in obese children and may well represent a targetable risk factor. Technological advancements in recent years have facilitated noninvasive measurements of endothelial homeostasis in children. Thereby this topic ultimately starts to get the attention it deserves. In this paper, we aim to summarize the latest insights on endothelial dysfunction in childhood obesity. We discuss methodological advancements in peripheral endothelial function measurement and newly identified diagnostic markers of vascular homeostasis. Finally, future challenges and perspectives are set forth on how to efficiently tackle the catastrophic rise in cardiovascular morbidity and mortality that will be inflicted on obese children if they are not treated optimally.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endotelio Vascular / Obesidad Infantil Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Pediatr Res Año: 2016 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endotelio Vascular / Obesidad Infantil Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Pediatr Res Año: 2016 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos