Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.

Zhang, Wei; Zhai, Ling; Lu, Wenyan; Boohaker, Rebecca J; Padmalayam, Indira; Li, Yonghe

Zhang, Wei; Zhai, Ling; Lu, Wenyan; Boohaker, Rebecca J; Padmalayam, Indira; Li, Yonghe.

Afiliación

Zhang W; Drug Discovery Division, Southern Research Institute, 2000 9th Avenue South, Birmingham, AL, USA.
Zhai L; Drug Discovery Division, Southern Research Institute, 2000 9th Avenue South, Birmingham, AL, USA.
Lu W; Drug Discovery Division, Southern Research Institute, 2000 9th Avenue South, Birmingham, AL, USA.
Boohaker RJ; Drug Discovery Division, Southern Research Institute, 2000 9th Avenue South, Birmingham, AL, USA.
Padmalayam I; Drug Discovery Division, Southern Research Institute, 2000 9th Avenue South, Birmingham, AL, USA.
Li Y; Drug Discovery Division, Southern Research Institute, 2000 9th Avenue South, Birmingham, AL, USA.

Chem Biol Drug Des ; 88(2): 178-87, 2016 08.

Article en En | MEDLINE | ID: mdl-26864917

Asunto(s)

Cinesinas/antagonistas & inhibidores; Regulación Alostérica; Línea Celular Tumoral; Neoplasias Colorrectales/patología; Descubrimiento de Drogas; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Microscopía Confocal; Estructura Molecular; Resonancia Magnética Nuclear Biomolecular

Palabras clave

drug discovery; enzymatic mechanism; structure-based drug design; virtual screening

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cinesinas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Chem Biol Drug Des Asunto de la revista: BIOQUIMICA / FARMACIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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