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Peri-implant bone adaptations to overloading in rat tibiae: experimental investigations and numerical predictions.
Piccinini, Marco; Cugnoni, Joel; Botsis, John; Ammann, Patrick; Wiskott, Anselm.
Afiliación
  • Piccinini M; Laboratory of applied mechanics and reliability analysis, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Cugnoni J; Laboratory of applied mechanics and reliability analysis, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Botsis J; Laboratory of applied mechanics and reliability analysis, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Ammann P; Division of bone diseases, Department of internal medicine specialities, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
  • Wiskott A; Division of fixed prosthodontics and biomaterials, University Clinics of Dental Medicine, University of Geneva, Geneva, Switzerland. Anselm.Wiskott@unige.ch.
Clin Oral Implants Res ; 27(11): 1444-1453, 2016 Nov.
Article en En | MEDLINE | ID: mdl-26864329
OBJECTIVES: (i) To assess the effects of mechanical overloading on implant integration in rat tibiae, and (ii) to numerically predict peri-implant bone adaptation. MATERIALS AND METHODS: Transcutaneous titanium implants were simultaneously placed into both tibiae of rats (n = 40). After 2 weeks of integration, the implants of the right tibiae were stimulated daily for 4 weeks with loads up to 5N (corresponding to peak equivalent strains of 3300 ± 500 µÎµ). The effects of stimulation were assessed by ex vivo mechanical tests and quantification of bone mineral density (BMD) in selected regions of interests (ROIs). Specimen-specific finite element models were generated and processed through an iterative algorithm to mimic bone adaptation. RESULTS: Bilateral implantation provoked an unstable integration that worsened when mild (2-4N) external loads were applied. In contrast, a stimulation at 5N tended to "counterbalance" the harmful effects of daily activity and, if applied to well-integrated specimens, significantly augmented the implants' resistance to failure (force: +73% P < 0.01, displacement: +50% P < 0.01 and energy: +153% P < 0.01). Specimen-specific numerical predictions were in close agreement with the experimental findings. Both local and overall BMD variations, as well as the implants' lateral stability, were predicted with small errors (0.14 gHA/cm3 and 0.64%, respectively). CONCLUSIONS: The rats' daily activity detrimentally affects implant integration. Conversely, external stimulations of large magnitudes counterbalance this effect and definitively improve integration. These changes can be predicted using the proposed numerical approach.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tibia / Implantes Dentales / Oseointegración / Implantación Dental Endoósea Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Clin Oral Implants Res Asunto de la revista: ODONTOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tibia / Implantes Dentales / Oseointegración / Implantación Dental Endoósea Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Clin Oral Implants Res Asunto de la revista: ODONTOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Dinamarca