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The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson's disease subjects.
Angelucci, Francesco; Piermaria, Jacopo; Gelfo, Francesca; Shofany, Jacob; Tramontano, Marco; Fiore, Marco; Caltagirone, Carlo; Peppe, Antonella.
Afiliación
  • Angelucci F; a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
  • Piermaria J; a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
  • Gelfo F; a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
  • Shofany J; b Department of Systemic Medicine, "Tor Vergata" University, Via Montpellier 1, 00133 Rome, Italy.
  • Tramontano M; a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
  • Fiore M; a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
  • Caltagirone C; c Institute of Cellular Biology and Neurobiology, CNR, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
  • Peppe A; a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
Can J Physiol Pharmacol ; 94(4): 455-61, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26863448
Increasing evidence suggests that motor rehabilitation may delay Parkinson's disease (PD) progression. Moreover, parallel treatments in animals up-regulate brain-derived neurotrophic factor (BDNF). Thus, we investigated the effect of a motor rehabilitation protocol on PD symptoms and BDNF serum levels. Motor rehabilitation training consisted of a cycle of 20 days/month of physiotherapy divided in 3 daily sessions. Clinical data were collected at the beginning, at the end, and at 90 days follow-up. BDNF serum levels were detected by ELISA at 0, 7, 14, 21, 30, and 90 days. The follow-up period had a duration of 60 days (T30-T90). The results showed that at the end of the treatment (day 30), an improvement in extrapyramidal signs (UPDRS III; UPDRS III - Gait and Balance items), motor (6 Minute Walking Test), and daily living activities (UPDRS II; PDQ-39) was observed. BDNF levels were increased at day 7 as compared with baseline. After that, no changes in BDNF were observed during the treatment and in the successive follow-up. This study demonstrates that motor rehabilitation training is able to ameliorate PD symptoms and to increase temporarily BDNF serum levels. The latter effect may potentially contribute to the therapeutic action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Factor Neurotrófico Derivado del Encéfalo / Actividad Motora Tipo de estudio: Diagnostic_studies / Guideline Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Can J Physiol Pharmacol Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Factor Neurotrófico Derivado del Encéfalo / Actividad Motora Tipo de estudio: Diagnostic_studies / Guideline Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Can J Physiol Pharmacol Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Canadá