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Chrysobalanus icaco L. Leaves Normalizes Insulin Sensitivity and Blood Glucose and Inhibits Weight Gain in High-Fat Diet-Induced Obese Mice.
White, Pollyanna A S; Araújo, Jessica M D; Cercato, Luana M; Souza, Lucas A; Barbosa, Ana Paula Oliveira; Quintans-Junior, Lucindo José; Machado, Ubiratan F; Camargo, Enilton A; Brito, Luciana C; Santos, Marcio Roberto V.
Afiliación
  • White PA; 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Araújo JM; 2 Núcleo de Nutrição, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Cercato LM; 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Souza LA; 2 Núcleo de Nutrição, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Barbosa AP; 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Quintans-Junior LJ; 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Machado UF; 3 Department of Physiology and Biophysic, Universidade de São Paulo , São Paulo, Brazil .
  • Camargo EA; 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Brito LC; 2 Núcleo de Nutrição, Universidade Federal de Sergipe , São Cristóvão, Brazil .
  • Santos MR; 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
J Med Food ; 19(2): 155-60, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26854845
Chrysobalanus icaco L. is a medicinal plant present in the Brazilian coastline and known for its hypoglicemic and antioxidant properties. Here, we assessed the beneficial metabolic effects of the aqueous extract of C. icaco (AECI) leaves in diet-induced obese mice. Swiss mice were fed standard chow (SC used as controls) or high-fat diet (HFD) to induce obesity. After 10 weeks, mice on each diet were divided into two groups with one group used as control while the other group treated with AECI for 4 weeks resulting in four groups of mice: SC; SC treated with AECI (SC + AECI); HFD; and HFD treated with AECI (HFD + AECI). AECI was administered drinking water at about 200 mg/kg. AECI was able to normalize insulin (13,682 ± 1090 vs. 9828 ± 485 AU, P < .05) and fasting blood glucose (192.8 ± 14.2 vs. 132.3 ± 6.4 mg/dL, P < .05) and inhibit weight gain (39 ± 5.7%) and fat storage in liver (72.60 ± 3.83%, P < .0001), despite the high-fat intake. These findings reinforce the use of AECI in hyperglycemia and highlight the potential extract's effect in preventing weight gain and fat accumulation in liver of diet-induced obese mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Resistencia a la Insulina / Extractos Vegetales / Aumento de Peso / Hojas de la Planta / Chrysobalanaceae Tipo de estudio: Diagnostic_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Med Food Asunto de la revista: CIENCIAS DA NUTRICAO / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Resistencia a la Insulina / Extractos Vegetales / Aumento de Peso / Hojas de la Planta / Chrysobalanaceae Tipo de estudio: Diagnostic_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Med Food Asunto de la revista: CIENCIAS DA NUTRICAO / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos