[The study of rs1800012 polymorphism of the alphal-chain collagen type 1 gene in Moscow women and children with different level of bone strength].
Vopr Pitan
; 84(4): 74-81, 2015.
Article
en Ru
| MEDLINE
| ID: mdl-26852534
The frequency of rs1800012 polymorphism of alpha1-chains of type 1 collagen gene (COL1A1) was studied by real-time PCR in 422 Moscow women and children, including pregnant women (n=96), lactating (n=29) and non-pregnant women (n=28) and preschool children (2-6 years, n=76) and school children (7-16 years, n=193) with different levels of bone strength (BS) as determined by ultrasound densitometry. It was found that the decrease in the value of the BS (Z-score < -1) was observed in 60% of women, 54% of preschool children and 48% of school-aged children. In the surveyed cohort the predominant genotype of rs1800012 polymorphism CO1A1 geneI gene was GG (55.1%), the frequency of the genotype TT--7.6%, of T-allele--26.2%. There were no statistically significant relationships of BS with a particular genotype of rs1800012 polymorphism 1f1COLIAI gene in all examined women. A positive but not statistically significant association of T allele with a risk BS reduction was found in non-pregnant and pregnant women (OR=2.143, p=0.31 and OR=1.227, p=0.55, respectively). For preschool and school-aged children T allele was not associated with the risk of BS reduction. In school-age children a statistically significant inverse association of T allele with the risk of BS reduction was shown (OR=0.621 wth
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Densidad Ósea
/
Colágeno Tipo I
/
Alelos
/
Genotipo
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
Ru
Revista:
Vopr Pitan
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Rusia