Your browser doesn't support javascript.
loading
Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice.
Baerenwaldt, Anne; von Burg, Nicole; Kreuzaler, Matthias; Sitte, Selina; Horvath, Edit; Peter, Annick; Voehringer, David; Rolink, Antonius G; Finke, Daniela.
Afiliación
  • Baerenwaldt A; University of Basel Children's Hospital, 4056 Basel, Switzerland; Developmental Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland;
  • von Burg N; University of Basel Children's Hospital, 4056 Basel, Switzerland; Developmental Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland;
  • Kreuzaler M; Developmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland; and.
  • Sitte S; Department of Infection Biology, University Clinic of Erlangen, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
  • Horvath E; University of Basel Children's Hospital, 4056 Basel, Switzerland; Developmental Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland;
  • Peter A; University of Basel Children's Hospital, 4056 Basel, Switzerland; Developmental Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland;
  • Voehringer D; Department of Infection Biology, University Clinic of Erlangen, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
  • Rolink AG; Developmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland; and.
  • Finke D; University of Basel Children's Hospital, 4056 Basel, Switzerland; Developmental Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland; daniela.finke@unibas.ch.
J Immunol ; 196(6): 2561-71, 2016 Mar 15.
Article en En | MEDLINE | ID: mdl-26851220
Flt3 ligand (Flt3L) promotes survival of lymphoid progenitors in the bone marrow and differentiation of dendritic cells (DCs), but its role in regulating innate lymphoid cells (ILCs) during fetal and adult life is not understood. By using Flt3L knockout and transgenic mice, we demonstrate that Flt3L controls ILC numbers by regulating the pool of α4ß7(-) and α4ß7(+) lymphoid tissue inducer cell progenitors in the fetal liver and common lymphoid progenitors in the bone marrow. Deletion of flt3l severely reduced the number of fetal liver progenitors and lymphoid tissue inducer cells in the neonatal intestine, resulting in impaired development of Peyer's patches. In the adult intestine, NK cells and group 2 and 3 ILCs were severely reduced. This effect occurred independently of DCs as ILC numbers were normal in mice in which DCs were constitutively deleted. Finally, we could show that administration of Flt3L increased the number of NKp46(-) group 3 ILCs in wild-type and even in Il7(-/-) mice, which generally have reduced numbers of ILCs. Taken together, Flt3L significantly contributes to ILC and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglios Linfáticos Agregados / Linfopoyesis / Células Progenitoras Linfoides / Inmunidad Innata / Proteínas de la Membrana Límite: Animals Idioma: En Revista: J Immunol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglios Linfáticos Agregados / Linfopoyesis / Células Progenitoras Linfoides / Inmunidad Innata / Proteínas de la Membrana Límite: Animals Idioma: En Revista: J Immunol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos