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Clinical Manifestations and Outcome of Syphilitic Uveitis.
Bollemeijer, Jan G; Wieringa, Wietse G; Missotten, Tom O A R; Meenken, Ina; ten Dam-van Loon, Ninette H; Rothova, Aniki; Los, Leonoor I.
Afiliación
  • Bollemeijer JG; Rotterdam Eye Hospital, Rotterdam, The Netherlands 2Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
  • Wieringa WG; Department of Ophthalmology, University Medical Center Groningen, Groningen, The Netherlands 4W. J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands.
  • Missotten TO; Rotterdam Eye Hospital, Rotterdam, The Netherlands.
  • Meenken I; Department of Ophthalmology, VU University Medical Center, Amsterdam, The Netherlands.
  • ten Dam-van Loon NH; Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Rothova A; Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands 7Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Los LI; Department of Ophthalmology, University Medical Center Groningen, Groningen, The Netherlands 4W. J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands.
Invest Ophthalmol Vis Sci ; 57(2): 404-11, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26848879
PURPOSE: To analyze visual outcome, effectiveness of various modes of antibiotic treatment, and prognostic factors in patients with serologically proven syphilitic uveitis. METHODS: The clinical records of 85 patients (139 eyes) diagnosed with syphilitic uveitis between 1984 and 2013 at tertiary centers in The Netherlands were retrospectively analyzed. RESULTS: Mean age was 47 years (range, 27-73 years), 82.4% were male. HIV positivity was found in 28 (35.9%) patients; 13 were newly diagnosed. Most patients had pan (45.9%) or posterior (31.8%) uveitis. On average, logMAR visual acuity (VA) improved significantly from 0.55 at the start of syphilis treatment to 0.34 at 1 month and to 0.27 at 6 months follow-up. Most patients (86.7%) reached disease remission. No differences in efficacy between the various treatment regimens were found. A high logMAR VA at the start of syphilis treatment and a treatment delay of more than 12 weeks were prognostic for a high logMAR VA at 6 months follow-up. Chronicity was not related to any form of treatment, HIV status, or Venereal Disease Research Laboratory test outcome. CONCLUSIONS: In this large cohort of 85 patients with syphilitic uveitis, visual outcomes were favorable in the majority of cases. Visual outcome was dependent on VA at the start of syphilis treatment and treatment delay.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Sífilis / Infecciones Bacterianas del Ojo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest Ophthalmol Vis Sci Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Sífilis / Infecciones Bacterianas del Ojo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest Ophthalmol Vis Sci Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos