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A survey of fertility and sexual health following allogeneic haematopoietic stem cell transplantation in New South Wales, Australia.
Dyer, Gemma; Gilroy, Nicole; Bradford, Jennifer; Brice, Lisa; Kabir, Masura; Greenwood, Matt; Larsen, Stephen R; Moore, John; Hertzberg, Mark; Kwan, John; Brown, Louisa; Hogg, Megan; Huang, Gillian; Tan, Jeff; Ward, Christopher; Kerridge, Ian.
Afiliación
  • Dyer G; Northern Clinical School, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.
  • Gilroy N; Blood and Marrow Transplant Network, New South Wales Agency for Clinical Innovation, Sydney, NSW, Australia.
  • Bradford J; Blood and Marrow Transplant Network, New South Wales Agency for Clinical Innovation, Sydney, NSW, Australia.
  • Brice L; Department of Obstetrics & Gynaecology, Westmead Hospital, Sydney, NSW, Australia.
  • Kabir M; Department of Haematology, Royal North Shore Hospital, Sydney, NSW, Australia.
  • Greenwood M; Westmead Breast Cancer Institute, Sydney, NSW, Australia.
  • Larsen SR; Northern Clinical School, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.
  • Moore J; Department of Haematology, Royal North Shore Hospital, Sydney, NSW, Australia.
  • Hertzberg M; Northern Blood Research Centre, Kolling Institute, University of Sydney, Sydney, NSW, Australia.
  • Kwan J; Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
  • Brown L; Department of Haematology, St Vincent Hospital, Sydney, NSW, Australia.
  • Hogg M; Department of Haematology, Prince of Wales Hospital, Sydney, NSW, Australia.
  • Huang G; Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.
  • Tan J; Department of Haematology, Newcastle Mater Hospital, Sydney, NSW, Australia.
  • Ward C; Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.
  • Kerridge I; Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.
Br J Haematol ; 172(4): 592-601, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26847746
Four hundred and twenty-one adult allogeneic haematopoietic stem cell transplant (HSCT) survivors participated in a cross-sectional study to assess sexual dysfunction and infertility post-transplant. Survey instruments included the Sydney Post-Blood and Marrow Transplant (BMT) Survey, Functional Assessment of Cancer Treatment (FACT) - BMT, the Depression, Anxiety, Stress Scales (DASS 21), the Chronic Graft-versus-Host Disease (cGVHD) Activity Assessment- Patient Self Report (Form B), the Lee cGVHD Symptom Scale and The Post-Traumatic Growth Inventory. Most HSCT survivors reported sexual difficulties (51% of males; 66% of females). Men reported erectile dysfunction (79%) and decreased libido (61·6%) and women reported loss of libido (83%), painful intercourse (73%) and less enjoyment of sex (68%). Women also commonly reported vaginal dryness (73%), vaginal narrowing (34%) and vaginal irritation (26%). Woman had much higher rates of genital cGvHD than men (22% vs. 5%). Age and cGVHD were significantly associated with sexual dysfunction. Few survivors had children following transplant (3·3%). However, for those of reproductive age at HSCT, 22% reported trying to conceive, with 10·3% reporting success. This study is the largest to date exploring sexual function in survivors of allo-HSCT. This data provides the basis for health service reform to better meet the needs of HSCT survivors, including evidence to support counselling and education both pre- and post-transplant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunciones Sexuales Fisiológicas / Trasplante de Células Madre Hematopoyéticas / Infertilidad Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Br J Haematol Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunciones Sexuales Fisiológicas / Trasplante de Células Madre Hematopoyéticas / Infertilidad Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Br J Haematol Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido