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Virology, serology, and demography of hepatitis E viremic blood donors in South East England.
Tedder, Richard S; Tettmar, Kate I; Brailsford, Su R; Said, Bengu; Ushiro-Lumb, Ines; Kitchen, Alan; Morgan, Dilys; Lattimore, Sam; Tossell, Joanne; Ijaz, Samreen; Hewitt, Patricia E.
Afiliación
  • Tedder RS; Microbiology Services, National Health Service Blood and Transplant, London.
  • Tettmar KI; Blood Borne Virus Unit, Virus Reference Department, National Infection Service.
  • Brailsford SR; University College London, London, UK.
  • Said B; Microbiology Services, National Health Service Blood and Transplant, London.
  • Ushiro-Lumb I; Blood Borne Virus Unit, Virus Reference Department, National Infection Service.
  • Kitchen A; Microbiology Services, National Health Service Blood and Transplant, London.
  • Morgan D; NHSBT/PHE Epidemiology Unit, Department of Immunisation, Hepatitis and Blood Safety.
  • Lattimore S; Emerging Infections and Zoonoses, National Infection Service, Public Health England, London.
  • Tossell J; Microbiology Services, National Health Service Blood and Transplant, London.
  • Ijaz S; Blood Borne Virus Unit, Virus Reference Department, National Infection Service.
  • Hewitt PE; Microbiology Services, National Health Service Blood and Transplant, London.
Transfusion ; 56(6 Pt 2): 1529-36, 2016 06.
Article en En | MEDLINE | ID: mdl-26841005
BACKGROUND: Hepatitis E virus (HEV) Genotype 3 (G3) in England comprises two principal phylogenetic groups (Group 1 and Group 2) and can be transmitted by transfusion. Unselected screening identified 79 viremic donors; 76 participated in a follow-up study. STUDY DESIGN AND METHODS: Viral RNA dynamics, phylogenetics, and seroconversion were characterized in the donors. Detailed demographic, travel, clinical, and lifestyle questionnaires were undertaken. RESULTS: The majority of viremic individuals (57/79) were seronegative at time of donation but all seroconverted. Viremia was short-lived, with a median of 6.5 weeks to confirmed viral clearance. All infections were acquired in the United Kingdom and were G3, with Group 2 viruses predominating (43/54; 80%). Infection was associated with some clinical symptoms both at and after donation (8/77; 10%). Viral loads and symptoms were more pronounced in Group 1 infections. There was no serologic evidence of reinfection. Donors were more commonly male (p = 0.002); both male and female donors were older than comparator donors. Animal contact was unlikely to be the source of infection. Consumption of chicken and pig meat was common to all infected donors; processed pig meat was most commonly purchased from one particular retail chain. CONCLUSION: Viremic donors represent primary infection in older members of the community and reflect a widespread zoonotic in the United Kingdom. The two phylogenetic groups of HEV G3 display different pathogenicity and the more common Group 2 appears less adapted to humans. There are no objective demographic criteria that can identify donors at enhanced HEV risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Sangre / Virus de la Hepatitis E / Hepatitis E Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Transfusion Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Sangre / Virus de la Hepatitis E / Hepatitis E Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Transfusion Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos