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Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure.
Esmekaya, Meric Arda; Tuysuz, Mehmet Zahid; Tomruk, Arin; Canseven, Ayse G; Yücel, Engin; Aktuna, Zuhal; Keskil, Semih; Seyhan, Nesrin.
Afiliación
  • Esmekaya MA; Department of Biophysics, Gazi University, Ankara, Turkey. Electronic address: mericarda@yahoo.com.
  • Tuysuz MZ; Department of Biophysics, Gazi University, Ankara, Turkey.
  • Tomruk A; Department of Biophysics, Gazi University, Ankara, Turkey.
  • Canseven AG; Department of Biophysics, Gazi University, Ankara, Turkey.
  • Yücel E; Department of Neurosurgery, Baskent University, Alanya Training and Research Hospital, Antalya, TURKEY.
  • Aktuna Z; Department of Medical Pharmacology, Kirikkale University, Kirikkale, TURKEY.
  • Keskil S; Department of Neurosurgery, Kirikkale University, Kirikkale, TURKEY.
  • Seyhan N; Department of Biophysics, Gazi University, Ankara, Turkey.
J Chem Neuroanat ; 75(Pt B): 111-5, 2016 09.
Article en En | MEDLINE | ID: mdl-26836107
The objective of the this study was to evaluate the effects of cellular phone radiation on oxidative stress parameters and oxide levels in mouse brain during pentylenetetrazole (PTZ) induced epileptic seizure. Eight weeks old mice were used in the study. Animals were distributed in the following groups: Group I: Control group treated with PTZ, Group II: 15min cellular phone radiation+PTZ treatment+30min cellular phone radiation, Group III: 30min cellular phone radiation+PTZ treatment+30min cellular phone radiation. The RF radiation was produced by a 900MHz cellular phone. Lipid peroxidation, which is the indicator of oxidative stress was quantified by measuring the formation of thiobarbituric acid reactive substances (TBARS). The glutathione (GSH) levels were determined by the Ellman method. Tissue total nitric oxide (NOx) levels were obtained using the Griess assay. Lipid peroxidation and NOx levels of brain tissue increased significantly in group II and III compared to group I. On the contrary, GSH levels were significantly lower in group II and III than group I. However, no statistically significant alterations in any of the endpoints were noted between group II and Group III. Overall, the experimental findings demonstrated that cellular phone radiation may increase the oxidative damage and NOx level during epileptic activity in mouse brain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Encéfalo / Peroxidación de Lípido / Teléfono Celular / Glutatión / Óxido Nítrico Límite: Animals Idioma: En Revista: J Chem Neuroanat Asunto de la revista: ANATOMIA / NEUROLOGIA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Encéfalo / Peroxidación de Lípido / Teléfono Celular / Glutatión / Óxido Nítrico Límite: Animals Idioma: En Revista: J Chem Neuroanat Asunto de la revista: ANATOMIA / NEUROLOGIA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos