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Prenatal ß-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.
Belinson, H; Nakatani, J; Babineau, B A; Birnbaum, R Y; Ellegood, J; Bershteyn, M; McEvilly, R J; Long, J M; Willert, K; Klein, O D; Ahituv, N; Lerch, J P; Rosenfeld, M G; Wynshaw-Boris, A.
Afiliación
  • Belinson H; Department of Pediatrics, Institute for Human Genetics, Edyth and Eli Broad Institute of Regenerative Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
  • Nakatani J; Department of Pediatrics, Institute for Human Genetics, Edyth and Eli Broad Institute of Regenerative Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
  • Babineau BA; Department of Pediatrics, Institute for Human Genetics, Edyth and Eli Broad Institute of Regenerative Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
  • Birnbaum RY; Department of Life Sciences, Ben-Gurion University at the Negev, Beer-Sheva, Israel.
  • Ellegood J; Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada.
  • Bershteyn M; Department of Pediatrics, Institute for Human Genetics, Edyth and Eli Broad Institute of Regenerative Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
  • McEvilly RJ; Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
  • Long JM; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institute of Health, Baltimore, MD, USA.
  • Willert K; Deparment of Cell and Molecular Biology, Institute for Regenerative Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
  • Klein OD; Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, CA, USA.
  • Ahituv N; Department of Bioengineering and Therapeutic Sciences, Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.
  • Lerch JP; Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada.
  • Rosenfeld MG; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Wynshaw-Boris A; Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Mol Psychiatry ; 21(10): 1417-33, 2016 10.
Article en En | MEDLINE | ID: mdl-26830142
Social interaction is a fundamental behavior in all animal species, but the developmental timing of the social neural circuit formation and the cellular and molecular mechanisms governing its formation are poorly understood. We generated a mouse model with mutations in two Disheveled genes, Dvl1 and Dvl3, that displays adult social and repetitive behavioral abnormalities associated with transient embryonic brain enlargement during deep layer cortical neuron formation. These phenotypes were mediated by the embryonic expansion of basal neural progenitor cells (NPCs) via deregulation of a ß-catenin/Brn2/Tbr2 transcriptional cascade. Transient pharmacological activation of the canonical Wnt pathway during this period of early corticogenesis rescued the ß-catenin/Brn2/Tbr2 transcriptional cascade and the embryonic brain phenotypes. Remarkably, this embryonic treatment prevented adult behavioral deficits and partially rescued abnormal brain structure in Dvl mutant mice. Our findings define a mechanism that links fetal brain development and adult behavior, demonstrating a fetal origin for social and repetitive behavior deficits seen in disorders such as autism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno de Movimiento Estereotipado Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno de Movimiento Estereotipado Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido