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The role of IL-11 in immunity and cancer.
Xu, Dixon H; Zhu, Ziwen; Wakefield, Mark R; Xiao, Huaping; Bai, Qian; Fang, Yujiang.
Afiliación
  • Xu DH; Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, USA.
  • Zhu Z; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
  • Wakefield MR; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
  • Xiao H; Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, USA; The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, China.
  • Bai Q; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
  • Fang Y; Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, USA; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address: yujiang.fang@dmu.edu.
Cancer Lett ; 373(2): 156-63, 2016 Apr 10.
Article en En | MEDLINE | ID: mdl-26826523
Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that utilizes the GP-130 signaling pathway shared by other cytokines of the same family. Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a proinflammatory cytokine, suggesting its complex role in immune response. In recent years, IL-11 has an emerging role in various inflammation-associated cancers. In this review, we aim to discuss IL-11 signaling pathway, to explore the role of IL-11 in immunity and various cancers, and to provide a therapeutic perspective of strategies utilized to interfere IL-11 signaling in cancer cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-11 / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cancer Lett Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-11 / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cancer Lett Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda