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Non-motor symptoms in patients with hereditary spastic paraplegia caused by SPG4 mutations.
Servelhere, K R; Faber, I; Saute, J A M; Moscovich, M; D'Abreu, A; Jardim, L B; Teive, H A G; Lopes-Cendes, I; Franca, M C.
Afiliación
  • Servelhere KR; Department of Neurology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
  • Faber I; Department of Neurology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
  • Saute JA; Medical Genetics Service, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil.
  • Moscovich M; Neurology Service, Federal University of Paraná - UFPR, Curitiba, PR, Brazil.
  • D'Abreu A; Department of Neurology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
  • Jardim LB; Medical Genetics Service, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil.
  • Teive HA; Neurology Service, Federal University of Paraná - UFPR, Curitiba, PR, Brazil.
  • Lopes-Cendes I; Department of Medical Genetics, University of Campinas - UNICAMP, Campinas, SP, Brazil.
  • Franca MC; Department of Neurology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
Eur J Neurol ; 23(2): 408-11, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26806216
BACKGROUND AND PURPOSE: Non-motor manifestations are frequently overlooked in degenerative disorders and little is known about their frequency and clinical relevance in SPG4 hereditary spastic paraplegia (SPG4-HSP). METHODS: Thirty patients with SPG4-HSP and 30 healthy controls answered the Modified Fatigue Impact Scale, Epworth Sleepiness Scale, Brief Pain Inventory and Beck Depression Inventory. Student's t test was used to compare groups and linear regression was used to assess correlations. RESULTS: Patients had higher fatigue scores than controls (31.0 ± 16.5 vs. 14.5 ± 16.0, P = 0.002) as well as pain (3.4 ± 2.7 vs. 1.0 ± 1.6, P = 0.001) and depression (12.7 ± 8.9 vs. 4.4 ± 3.8, P < 0.001, respectively). Fatigue was associated with depression and possibly with disease severity (P = 0.008 and 0.07, respectively). CONCLUSIONS: Fatigue, pain and depression are frequent and often severe manifestations in patients with SPG4-HSP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Paraplejía Espástica Hereditaria / Depresión / Fatiga Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Paraplejía Espástica Hereditaria / Depresión / Fatiga Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido