EASE-MM: Sequence-Based Prediction of Mutation-Induced Stability Changes with Feature-Based Multiple Models.

Folkman, Lukas; Stantic, Bela; Sattar, Abdul; Zhou, Yaoqi

Folkman, Lukas; Stantic, Bela; Sattar, Abdul; Zhou, Yaoqi.

Afiliación

Folkman L; Institute for Integrated and Intelligent Systems, Griffith University, 170 Kessels Road, Brisbane, Queensland 4111, Australia; Queensland Research Laboratory, NICTA, National ICT Australia, 70-72 Bowen Street, Spring Hill, Queensland 4000, Australia. Electronic address: lukas.folkman@griffithuni.edu
Stantic B; Institute for Integrated and Intelligent Systems, Griffith University, 170 Kessels Road, Brisbane, Queensland 4111, Australia. Electronic address: b.stantic@griffith.edu.au.
Sattar A; Institute for Integrated and Intelligent Systems, Griffith University, 170 Kessels Road, Brisbane, Queensland 4111, Australia; Queensland Research Laboratory, NICTA, National ICT Australia, 70-72 Bowen Street, Spring Hill, Queensland 4000, Australia. Electronic address: a.sattar@griffith.edu.au.
Zhou Y; Institute for Integrated and Intelligent Systems, Griffith University, 170 Kessels Road, Brisbane, Queensland 4111, Australia; Institute for Glycomics, Griffith University, Parklands Drive, Southport, Queensland 4222, Australia. Electronic address: yaoqi.zhou@griffith.edu.au.

J Mol Biol ; 428(6): 1394-1405, 2016 Mar 27.

Article en En | MEDLINE | ID: mdl-26804571

Asunto(s)

Biología Computacional/métodos; Mutación Missense; Ingeniería de Proteínas/métodos; Estabilidad Proteica; Proteínas/química; Proteínas/genética; Sustitución de Aminoácidos; Humanos; Modelos Moleculares

Palabras clave

amino acid substitution; free energy change; machine learning; missense mutation; non-synonymous SNV

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingeniería de Proteínas / Proteínas / Biología Computacional / Mutación Missense / Estabilidad Proteica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Mol Biol Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos

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