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Diversity of STs, plasmids and ESBL genes among Escherichia coli from humans, animals and food in Germany, the Netherlands and the UK.
Day, Michaela J; Rodríguez, Irene; van Essen-Zandbergen, Alieda; Dierikx, Cindy; Kadlec, Kristina; Schink, Anne-Kathrin; Wu, Guanghui; Chattaway, Marie A; DoNascimento, Vivienne; Wain, John; Helmuth, Reiner; Guerra, Beatriz; Schwarz, Stefan; Threlfall, John; Woodward, Martin J; Coldham, Nick; Mevius, Dik; Woodford, Neil.
Afiliación
  • Day MJ; Public Health England, London, UK michaela.day@phe.gov.uk.
  • Rodríguez I; Federal Institute for Risk Assessment (BfR), Berlin, Germany University Hospital Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
  • van Essen-Zandbergen A; Central Veterinary Institute (CVI) of Wageningen UR, Lelystad, The Netherlands.
  • Dierikx C; Central Veterinary Institute (CVI) of Wageningen UR, Lelystad, The Netherlands.
  • Kadlec K; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Neustadt-Mariensee, Germany.
  • Schink AK; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Neustadt-Mariensee, Germany.
  • Wu G; Animal and Plant Health Agency (APHA, Weybridge), Addlestone, UK.
  • Chattaway MA; Public Health England, London, UK.
  • DoNascimento V; Public Health England, London, UK.
  • Wain J; University of East Anglia, Norwich, UK.
  • Helmuth R; Federal Institute for Risk Assessment (BfR), Berlin, Germany.
  • Guerra B; Federal Institute for Risk Assessment (BfR), Berlin, Germany.
  • Schwarz S; Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Neustadt-Mariensee, Germany.
  • Threlfall J; Public Health England, London, UK.
  • Woodward MJ; The University of Reading, Whiteknights, Reading, UK.
  • Coldham N; Animal and Plant Health Agency (APHA, Weybridge), Addlestone, UK.
  • Mevius D; Central Veterinary Institute (CVI) of Wageningen UR, Lelystad, The Netherlands Utrecht University, Utrecht, The Netherlands.
  • Woodford N; Public Health England, London, UK.
J Antimicrob Chemother ; 71(5): 1178-82, 2016 May.
Article en En | MEDLINE | ID: mdl-26803720
OBJECTIVES: This study aimed to compare ESBL-producing Escherichia coli causing infections in humans with infecting or commensal isolates from animals and isolates from food of animal origin in terms of the strain types, the ESBL gene present and the plasmids that carry the respective ESBL genes. METHODS: A collection of 353 ESBL-positive E. coli isolates from the UK, the Netherlands and Germany were studied by MLST and ESBL genes were identified. Characterization of ESBL gene-carrying plasmids was performed using PCR-based replicon typing. Moreover, IncI1-Iγ and IncN plasmids were characterized by plasmid MLST. RESULTS: The ESBL-producing E. coli represented 158 different STs with ST131, ST10 and ST88 being the most common. Overall, blaCTX-M-1 was the most frequently detected ESBL gene, followed by blaCTX-M-15, which was the most common ESBL gene in the human isolates. The most common plasmid replicon type overall was IncI1-Iγ followed by multiple IncF replicons. CONCLUSIONS: ESBL genes were present in a wide variety of E. coli STs. IncI1-Iγ plasmids that carried the blaCTX-M-1 gene were widely disseminated amongst STs in isolates from animals and humans, whereas other plasmids and STs appeared to be more restricted to isolates from specific hosts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plásmidos / Toxinas Bacterianas / Beta-Lactamasas / Proteínas de Escherichia coli / Enterotoxinas / Escherichia coli / Infecciones por Escherichia coli / Microbiología de Alimentos Límite: Animals / Humans País/Región como asunto: Europa Idioma: En Revista: J Antimicrob Chemother Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plásmidos / Toxinas Bacterianas / Beta-Lactamasas / Proteínas de Escherichia coli / Enterotoxinas / Escherichia coli / Infecciones por Escherichia coli / Microbiología de Alimentos Límite: Animals / Humans País/Región como asunto: Europa Idioma: En Revista: J Antimicrob Chemother Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido