Stable isotope-assisted LC-MS/MS monitoring of glyceryl trinitrate bioactivation in a cell culture model of nitrate tolerance.

Axton, Elizabeth R; Hardardt, Elizabeth A; Stevens, Jan F

Axton, Elizabeth R; Hardardt, Elizabeth A; Stevens, Jan F.

Afiliación

Axton ER; The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States; Department of Environmental and Molecular Toxicology(,) Oregon State University, Corvallis, OR 97331, United States; Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, United States. Electronic address: axtone@oregonstate.edu.
Hardardt EA; The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States; Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, United States.
Stevens JF; The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States; Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, United States. Electronic address: fred.stevens@oregonstate.edu.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1019: 156-63, 2016 Apr 15.

Article en En | MEDLINE | ID: mdl-26796748

Asunto(s)

Cromatografía Liquida/métodos; Células Endoteliales/metabolismo; Marcaje Isotópico/métodos; Nitratos/metabolismo; Nitroglicerina/metabolismo; Espectrometría de Masas en Tándem/métodos; Línea Celular; Células Endoteliales/química; Humanos; Nitratos/química; Nitritos/química; Nitritos/metabolismo; Isótopos de Nitrógeno/análisis; Isótopos de Nitrógeno/metabolismo; Nitroglicerina/química

Palabras clave

Cell culture; Glyceryl trinitrate; LCMS/MS; Nitrate tolerance; Nitric oxide; Nitrite

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatografía Liquida / Nitroglicerina / Células Endoteliales / Espectrometría de Masas en Tándem / Marcaje Isotópico / Nitratos Tipo de estudio: Evaluation_studies Límite: Humans Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos

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