Your browser doesn't support javascript.
loading
Physiological and cytokine response to acute exercise under hypoxic conditions: a pilot study.
Lira, Fábio S; Lemos, Valdir A; Bittar, Irene G; Caris, Aline V; Dos Santos, Ronaldo V; Tufik, Sergio; Zagatto, Alessandro M; de Souza, Claudio T; Pimentel, Gustavo D; De Mello, Marco T.
Afiliación
  • Lira FS; Exercise and Immunometabolism Research Group, Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente, Brazil - fabiolira@fct.unesp.br.
  • Lemos VA; Department of Psychobiology, São Paulo Federal University (UNIFESP), São Paulo, Brazil.
  • Bittar IG; Center for Studies in Psychobiology and Physical Exercise (CEPE), São Paulo, Brazil.
  • Caris AV; Department of Psychobiology, São Paulo Federal University (UNIFESP), São Paulo, Brazil.
  • Dos Santos RV; Department of Biosciences, São Paulo Federal University (UNIFESP), Santos, Brazil.
  • Tufik S; Department of Biosciences, São Paulo Federal University (UNIFESP), Santos, Brazil.
  • Zagatto AM; Department of Psychobiology, São Paulo Federal University (UNIFESP), São Paulo, Brazil.
  • de Souza CT; Department of Physical Education, Faculty of Sciences, São Paulo State University (UNESP), Bauru, Brazil.
  • Pimentel GD; Laboratory of Exercise Biochemistry and Physiology, Health Sciences Unit, University of the Extreme South of Santa Catarina, Criciúma, Brazil.
  • De Mello MT; Laboratory for Investigation on Clinical and Sports Nutrition (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil.
J Sports Med Phys Fitness ; 57(4): 461-468, 2017 Apr.
Article en En | MEDLINE | ID: mdl-26796076
BACKGROUND: Studies have demonstrated that exercise in hypoxia situations induces a cytotoxicity effects. However, the cytokines participation in this condition is remaining unknown. Thus, the aim the present study was to evaluate physiological parameters and inflammatory profiles in response to acute exercise after five hours of hypoxic conditions. METHODS: Fourteen healthy men were distributed randomly into two groups: normoxic exercise (N.=7) and hypoxic exercise (N.=7). All volunteers were blinded to the protocol. Initially, all subjects were submitted to chamber normobaric in a room fitted for altitude simulations of up to 4500 m, equivalent to a barometric pressure of 433 mmHg. All analyses began at 7:00 a.m. and was maintained for 5 hours; the fraction of inspired oxygen (FiO2) was 13.5%. The groups began a 60-minute session of physical exercise starting at 11:00 a.m., at 50% of peak VO2 (50% VO2peak). Blood was collected for cytokine analysis in the morning upon waking, before the 60-minute exercise session and immediately thereafter. RESULTS: The heart rate during 60 minutes' exercise training was significantly increased in both exercise groups (P<0.05), and the oxygen saturation was reduced under hypoxic conditions during exercise (P<0.05). After exercise, significant increases were found for IL-1ra and IL-10 under hypoxic conditions (P<0.05) and for IL-6 for both groups (P<0.05). TNF-α was not altered under either environmental condition. CONCLUSIONS: Our data demonstrate that acute exercise performance in hypoxic conditions can promotes early inflammatory response, leads for immunosuppression state.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Citocinas / Hipoxia Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: J Sports Med Phys Fitness Año: 2017 Tipo del documento: Article Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Citocinas / Hipoxia Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: J Sports Med Phys Fitness Año: 2017 Tipo del documento: Article Pais de publicación: Italia