Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.

Hearn, Brian R; Jaishankar, Priyadarshini; Sidrauski, Carmela; Tsai, Jordan C; Vedantham, Punitha; Fontaine, Shaun D; Walter, Peter; Renslo, Adam R

Hearn, Brian R; Jaishankar, Priyadarshini; Sidrauski, Carmela; Tsai, Jordan C; Vedantham, Punitha; Fontaine, Shaun D; Walter, Peter; Renslo, Adam R.

Afiliación

Hearn BR; Department of Pharmaceutical Chemistry and, Small Molecule Discovery Center, University of California, San Francisco, CA, 94158, USA.
Jaishankar P; Department of Pharmaceutical Chemistry and, Small Molecule Discovery Center, University of California, San Francisco, CA, 94158, USA.
Sidrauski C; Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA.
Tsai JC; Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA.
Vedantham P; Department of Pharmaceutical Chemistry and, Small Molecule Discovery Center, University of California, San Francisco, CA, 94158, USA.
Fontaine SD; Department of Pharmaceutical Chemistry and, Small Molecule Discovery Center, University of California, San Francisco, CA, 94158, USA.
Walter P; Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA. peter@walterlab.ucsf.edu.
Renslo AR; Department of Pharmaceutical Chemistry and, Small Molecule Discovery Center, University of California, San Francisco, CA, 94158, USA. adam.renslo@ucsf.edu.

ChemMedChem ; 11(8): 870-80, 2016 Apr 19.

Article en En | MEDLINE | ID: mdl-26789650

Asunto(s)

Factor 2 Eucariótico de Iniciación/metabolismo; Glicolatos/farmacología; Estrés Fisiológico/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Factor 2 Eucariótico de Iniciación/agonistas; Factor 2 Eucariótico de Iniciación/química; Glicolatos/síntesis química; Glicolatos/química; Células HEK293; Humanos; Estructura Molecular; Fosforilación/efectos de los fármacos; Unión Proteica/efectos de los fármacos; Relación Estructura-Actividad

Palabras clave

ISRIB; integrated stress response; protein-protein interactions; structure-activity relationships; unfolded protein response

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Factor 2 Eucariótico de Iniciación / Glicolatos Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

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