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Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis--A Cohort Study in a Group of Thyroid Carcinoma Patients.
Broeders, Evie P M; Vijgen, Guy H E J; Havekes, Bas; Bouvy, Nicole D; Mottaghy, Felix M; Kars, Marleen; Schaper, Nicolaas C; Schrauwen, Patrick; Brans, Boudewijn; van Marken Lichtenbelt, Wouter D.
Afiliación
  • Broeders EP; MUMC+, Department of Human Biology, Maastricht, the Netherlands.
  • Vijgen GH; MUMC+, Department of General Surgery, Maastricht, the Netherlands.
  • Havekes B; MUMC+, Department of Human Biology, Maastricht, the Netherlands.
  • Bouvy ND; St. Franciscus Gasthuis, Department of Surgery, Rotterdam, the Netherlands.
  • Mottaghy FM; MUMC+, Department of General Surgery, Maastricht, the Netherlands.
  • Kars M; MUMC+, Department of Endocrinology, Maastricht, the Netherlands.
  • Schaper NC; MUMC+, Department of General Surgery, Maastricht, the Netherlands.
  • Schrauwen P; MUMC+, Department of Nuclear Medicine, Maastricht, the Netherlands.
  • Brans B; Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany.
  • van Marken Lichtenbelt WD; MUMC+, Department of Endocrinology, Maastricht, the Netherlands.
PLoS One ; 11(1): e0145049, 2016.
Article en En | MEDLINE | ID: mdl-26784028
BACKGROUND/OBJECTIVES: Thyroid hormone receptors are present on brown adipose tissue (BAT), indicating a role for thyroid hormone in the regulation of BAT activation. The objective of this study was to examine the effect of thyroid hormone withdrawal followed by thyroid hormone in TSH-suppressive dosages, on energy expenditure and brown adipose tissue activity. SUBJECTS/METHODS: This study was a longitudinal study in an academic center, with a follow-up period of 6 months. Ten patients with well-differentiated thyroid carcinoma eligible for surgical treatment and subsequent radioactive iodine ablation therapy were studied in a hypothyroid state after thyroidectomy and in a subclinical hyperthyroid state (TSH-suppression according to treatment protocol). Paired two-tailed t-tests and linear regression analyses were used. RESULTS: Basal metabolic rate (BMR) was significantly higher after treatment with synthetic thyroid hormone (levothyroxine) than in the hypothyroid state (BMR 3.8 ± 0.5 kJ/min versus 4.4 ± 0.6 kJ/min, P = 0.012), and non-shivering thermogenesis (NST) significantly increased from 15 ± 10% to 25 ± 6% (P = 0.009). Mean BAT activity was significantly higher in the subclinical hyperthyroid state than in the hypothyroid state (BAT standard uptake value (SUVMean) 4.0 ± 2.9 versus 2.4 ± 1.8, P = 0.039). CONCLUSIONS: Our study shows that higher levels of thyroid hormone are associated with a higher level of cold-activated BAT. TRIAL REGISTRATION: ClinicalTrials.gov NCT02499471.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormonas Tiroideas / Tejido Adiposo Pardo / Neoplasias de la Tiroides / Termogénesis Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormonas Tiroideas / Tejido Adiposo Pardo / Neoplasias de la Tiroides / Termogénesis Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos