Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate esterAZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors.
Bioorg Med Chem
; 23(24): 7521-8, 2015 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-26775541
Novel 3-hydroxy-3-phenylpropanoate ester-azidothymidine (AZT) conjugates have been prepared using Baylis-Hillman methodology, and their potential as dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors has been explored using enzyme inhibition and computer modelling techniques; their activity and HeLa cell toxicity have been compared with those of their cinnamate ester analogues.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zidovudina
/
VIH-1
/
Inhibidores de la Transcriptasa Inversa
/
Inhibidores de Integrasa VIH
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Reino Unido