Simultaneous determination of tedizolid and linezolid in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.

Yu, Hua-chen; Pan, Chen-wei; Xie, Qi-peng; Zheng, Yi; Hu, Yue-zheng; Lin, Yi-mu

Yu, Hua-chen; Pan, Chen-wei; Xie, Qi-peng; Zheng, Yi; Hu, Yue-zheng; Lin, Yi-mu.

Afiliación

Yu HC; Department of Orthopaedic Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China. Electronic address: wzyuhc@163.com.
Pan CW; Department of Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Xie QP; Department of Laboratory Medicine, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Zheng Y; Department of Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Hu YZ; Department of Orthopaedic Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Lin YM; Department of Orthopaedic Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1011: 94-8, 2016 Feb 01.

Article en En | MEDLINE | ID: mdl-26773886

Asunto(s)

Cromatografía Líquida de Alta Presión/métodos; Linezolid/sangre; Linezolid/farmacocinética; Oxazolidinonas/sangre; Oxazolidinonas/farmacocinética; Espectrometría de Masas en Tándem/métodos; Tetrazoles/sangre; Tetrazoles/farmacocinética; Animales; Límite de Detección; Modelos Lineales; Linezolid/química; Masculino; Oxazolidinonas/química; Ratas; Ratas Sprague-Dawley; Reproducibilidad de los Resultados; Tetrazoles/química

Palabras clave

Linezolid; Rat plasma; Tedizolid; UPLC-MS/MS

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrazoles / Cromatografía Líquida de Alta Presión / Oxazolidinonas / Espectrometría de Masas en Tándem / Linezolid Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos

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