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New C-methylated flavonoids and α-pyrone derivative from roots of Talinum triangulare growing in Nigeria.
Umeokoli, Blessing O; Muharini, Rini; Okoye, Festus B; Ajiwe, Vincent I; Akpuaka, Mabel U; Lin, Wenhan; Liu, Zhen; Proksch, Peter.
Afiliación
  • Umeokoli BO; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany; Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
  • Muharini R; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
  • Okoye FB; Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
  • Ajiwe VI; Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
  • Akpuaka MU; Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
  • Lin W; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 100191 Beijing, China.
  • Liu Z; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. Electronic address: zhenfeizi0@sina.com.
  • Proksch P; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. Electronic address: proksch@uni-duesseldorf.de.
Fitoterapia ; 109: 169-73, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26773210
The first chemical examination of roots of the traditionally used medicinal plant Talinum triangulare (Portulacaceae) from Nigeria led to the isolation of two new C-methylated flavonoids, 5,6-dimethoxy-7-hydroxy-8-methyl-flavone (1), 5,6-dimethoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one (2), and one new α-pyrone derivative, 4-methoxy-6-(2-hydroxy-4-phenylbutyl)-2H-pyran-2-one (3), along with thirteen known compounds, including nine amides (4-12), indole-3-carboxylic acid (13), p-hydroxy benzoic acid (14), and two steroids (15-16). Their structures were elucidated by extensive spectroscopic measurements including 1D, 2D NMR, MS, and by comparison with the literature. All isolated compounds were screened for their cytotoxic and antifungal activities. However, none of them showed significant activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pironas / Flavonoides / Raíces de Plantas / Portulacaceae Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Fitoterapia Año: 2016 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pironas / Flavonoides / Raíces de Plantas / Portulacaceae Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Fitoterapia Año: 2016 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Países Bajos