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Prefrontal Parvalbumin Neurons in Control of Attention.
Kim, Hoseok; Ährlund-Richter, Sofie; Wang, Xinming; Deisseroth, Karl; Carlén, Marie.
Afiliación
  • Kim H; Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.
  • Ährlund-Richter S; Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.
  • Wang X; Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.
  • Deisseroth K; Howard Hughes Medical Institute, W080 Clark Center, 318 Campus Drive West, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, W080 Clark Center, 318 Campus Drive West, Stanford University, Stanford, CA 94305, USA; Department of Psychiatry and Behavioral Sciences, W080 Clark
  • Carlén M; Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden. Electronic address: marie.carlen@ki.se.
Cell ; 164(1-2): 208-218, 2016 Jan 14.
Article en En | MEDLINE | ID: mdl-26771492
While signatures of attention have been extensively studied in sensory systems, the neural sources and computations responsible for top-down control of attention are largely unknown. Using chronic recordings in mice, we found that fast-spiking parvalbumin (FS-PV) interneurons in medial prefrontal cortex (mPFC) uniformly show increased and sustained firing during goal-driven attentional processing, correlating to the level of attention. Elevated activity of FS-PV neurons on the timescale of seconds predicted successful execution of behavior. Successful allocation of attention was characterized by strong synchronization of FS-PV neurons, increased gamma oscillations, and phase locking of pyramidal firing. Phase-locked pyramidal neurons showed gamma-phase-dependent rate modulation during successful attentional processing. Optogenetic silencing of FS-PV neurons deteriorated attentional processing, while optogenetic synchronization of FS-PV neurons at gamma frequencies had pro-cognitive effects and improved goal-directed behavior. FS-PV neurons thus act as a functional unit coordinating the activity in the local mPFC circuit during goal-driven attentional processing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención / Corteza Prefrontal / Neuronas Límite: Animals Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención / Corteza Prefrontal / Neuronas Límite: Animals Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos