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Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children.
Choi, Jong Sub; Choi, Shin Jie; Lee, Kyung Jae; Kim, Ahlee; Yoo, Jung Kyung; Yang, Hye Ran; Moon, Jin Soo; Chang, Ju Young; Ko, Jae Sung; Kang, Gyeong Hoon.
Afiliación
  • Choi JS; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Choi SJ; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Lee KJ; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Kim A; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Yoo JK; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Yang HR; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Moon JS; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Chang JY; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Ko JS; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Kang GH; Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Pediatr Gastroenterol Hepatol Nutr ; 18(4): 253-60, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26770900
PURPOSE: The aim of the present study was to investigate the clinical features and outcome of eosinophilic gastroenteritis (EGE) in children. METHODS: Our study enrolled 24 children who were diagnosed with EGE from 1993 to 2014 at the Department of Pediatrics, Seoul National University Children's Hospital. The patients' clinical manifestations, treatments, and outcomes were reviewed from the medical records. RESULTS: The mean age at diagnosis was 5.3 years. Most patients had gastrointestinal symptoms including diarrhea (54.2%) and abdominal pain (45.8%). Peripheral eosinophilia was present in 91.7% of the patients. Thirteen patients (54.2%) showed anemia, and 15 patients (62.5%) had hypoalbuminemia. EGE was classified as mucosal, subserosal, or muscular in 75.0%, 20.8%, and 4.2% of cases, respectively. Three patients showed gastroduodenal ulcers upon endoscopic analysis. A history of allergy was reported in 13 patients, including atopic dermatitis, allergic rhinitis, and asthma. Five patients (20.8%) improved with food restrictions. Among the 19 patients treated with steroids, 11 (57.9%) discontinued steroid treatment without subsequent relapse, 4 (21.1%) relapsed after ceasing steroid treatment, and 4 (21.1%) showed no response to steroids. Two patients who were resistant to steroids underwent therapeutic surgery. The presence of gastroduodenal ulcers was significantly associated with relapse and steroid resistance. CONCLUSION: A high suspicion of EGE is warranted when children have nonspecific gastrointestinal symptoms and peripheral eosinophilia. Most patients improved with food restrictions or steroid treatment, although one-third of patients showed a relapse or steroid resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pediatr Gastroenterol Hepatol Nutr Año: 2015 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pediatr Gastroenterol Hepatol Nutr Año: 2015 Tipo del documento: Article Pais de publicación: Corea del Sur