Your browser doesn't support javascript.
loading
Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study.
Bagatell, Rochelle; McHugh, Kieran; Naranjo, Arlene; Van Ryn, Collin; Kirby, Chaim; Brock, Penelope; Lyons, Karen A; States, Lisa J; Rojas, Yesenia; Miller, Alexandra; Volchenboum, Sam L; Simon, Thorsten; Krug, Barbara; Sarnacki, Sabine; Valteau-Couanet, Dominique; von Schweinitz, Dietrich; Kammer, Birgit; Granata, Claudio; Pio, Luca; Park, Julie R; Nuchtern, Jed.
Afiliación
  • Bagatell R; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • McHugh K; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Naranjo A; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Van Ryn C; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Kirby C; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Brock P; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Lyons KA; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • States LJ; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Rojas Y; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Miller A; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Volchenboum SL; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Simon T; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Krug B; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Sarnacki S; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Valteau-Couanet D; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • von Schweinitz D; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Kammer B; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Granata C; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Pio L; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Park JR; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
  • Nuchtern J; Rochelle Bagatell, Lisa J. States, and Alexandra Miller, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Arlene Naranjo and Collin Van Ryn, University of Florida, Gainesville, FL; Chaim Kirby and Sam L. Volchenboum, University of Chicago, Chicago, IL; Karen A. L
J Clin Oncol ; 34(7): 740-6, 2016 Mar 01.
Article en En | MEDLINE | ID: mdl-26755515
PURPOSE: The International Neuroblastoma Response Criteria (INRC) require serial measurements of primary tumors in three dimensions, whereas the Response Evaluation Criteria in Solid Tumors (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of primary tumor response assessment for use in revised INRC. PATIENTS AND METHODS: Patients younger than 20 years with high-risk neuroblastoma were eligible if they were diagnosed between 2000 and 2012 and if three primary tumor measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as ≥ 30% reduction in longest dimension as per RECIST, ≥ 50% reduction in volume as per INRC, or ≥ 65% reduction in volume. RESULTS: Three-year event-free survival for all patients (N = 229) was 44% and overall survival was 58%. The sensitivity of both volume response measures (ability to detect responses in patients who survived) exceeded the sensitivity of the single dimension measure, but the specificity of all response measures (ability to identify lack of response in patients who later died) was low. In multivariable analyses, none of the response measures studied was predictive of outcome, and none was predictive of the extent of resection. CONCLUSION: None of the methods of primary tumor response assessment was predictive of outcome. Measurement of three dimensions followed by calculation of resultant volume is more complex than measurement of a single dimension. Primary tumor response in children with high-risk neuroblastoma should therefore be evaluated in accordance with RECIST criteria, using the single longest dimension.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neuroblastoma Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Clin Oncol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neuroblastoma Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Clin Oncol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos