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Meta-analysis of genome-wide association studies of anxiety disorders.
Otowa, T; Hek, K; Lee, M; Byrne, E M; Mirza, S S; Nivard, M G; Bigdeli, T; Aggen, S H; Adkins, D; Wolen, A; Fanous, A; Keller, M C; Castelao, E; Kutalik, Z; Van der Auwera, S; Homuth, G; Nauck, M; Teumer, A; Milaneschi, Y; Hottenga, J-J; Direk, N; Hofman, A; Uitterlinden, A; Mulder, C L; Henders, A K; Medland, S E; Gordon, S; Heath, A C; Madden, P A F; Pergadia, M L; van der Most, P J; Nolte, I M; van Oort, F V A; Hartman, C A; Oldehinkel, A J; Preisig, M; Grabe, H J; Middeldorp, C M; Penninx, B W J H; Boomsma, D; Martin, N G; Montgomery, G; Maher, B S; van den Oord, E J; Wray, N R; Tiemeier, H; Hettema, J M.
Afiliación
  • Otowa T; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
  • Hek K; Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
  • Lee M; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Byrne EM; Department of Psychiatry, Epidemiological and Social Psychiatric Research institute, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Mirza SS; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
  • Nivard MG; QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
  • Bigdeli T; Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
  • Aggen SH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Adkins D; Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
  • Wolen A; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
  • Fanous A; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
  • Keller MC; Department of Pharmacy, Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, VA, USA.
  • Castelao E; Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, USA.
  • Kutalik Z; Mental Health Service Line, Washington VA Medical Center, Washington DC, USA.
  • Van der Auwera S; Department of Psychiatry, Georgetown University School of Medicine, Washington DC, USA.
  • Homuth G; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
  • Nauck M; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
  • Teumer A; Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
  • Milaneschi Y; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
  • Hottenga JJ; Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
  • Direk N; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Hofman A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  • Uitterlinden A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst Moritz Arndt-University Greifswald, Greifswald, Germany.
  • Mulder CL; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Henders AK; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Medland SE; Department of Psychiatry, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands.
  • Gordon S; EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands.
  • Heath AC; Department of Psychiatry, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands.
  • Madden PA; EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands.
  • Pergadia ML; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • van der Most PJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Nolte IM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • van Oort FV; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Hartman CA; Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Oldehinkel AJ; QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
  • Preisig M; Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
  • Grabe HJ; QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
  • Middeldorp CM; QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
  • Penninx BW; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
  • Boomsma D; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
  • Martin NG; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
  • Montgomery G; Florida Atlantic University, Boca Raton, FL, USA.
  • Maher BS; Department of Genetic Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • van den Oord EJ; Department of Genetic Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Wray NR; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Tiemeier H; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Hettema JM; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Mol Psychiatry ; 21(10): 1391-9, 2016 10.
Article en En | MEDLINE | ID: mdl-26754954
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic definitions based on clinical presentation, ADs likely represent various expressions of an underlying common diathesis of abnormal regulation of basic threat-response systems. We conducted genome-wide association analyses in nine samples of European ancestry from seven large, independent studies. To identify genetic variants contributing to genetic susceptibility shared across interview-generated DSM-based ADs, we applied two phenotypic approaches: (1) comparisons between categorical AD cases and supernormal controls, and (2) quantitative phenotypic factor scores (FS) derived from a multivariate analysis combining information across the clinical phenotypes. We used logistic and linear regression, respectively, to analyze the association between these phenotypes and genome-wide single nucleotide polymorphisms. Meta-analysis for each phenotype combined results across the nine samples for over 18 000 unrelated individuals. Each meta-analysis identified a different genome-wide significant region, with the following markers showing the strongest association: for case-control contrasts, rs1709393 located in an uncharacterized non-coding RNA locus on chromosomal band 3q12.3 (P=1.65 × 10(-8)); for FS, rs1067327 within CAMKMT encoding the calmodulin-lysine N-methyltransferase on chromosomal band 2p21 (P=2.86 × 10(-9)). Independent replication and further exploration of these findings are needed to more fully understand the role of these variants in risk and expression of ADs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido