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Impact of Angiotensin-II receptor blockers on vasogenic edema in glioblastoma patients.
Kourilsky, Antoine; Bertrand, Guillaume; Ursu, Renata; Doridam, Jennifer; Barlog, Ciprian; Faillot, Thierry; Mandonnet, Emmanuel; Belin, Catherine; Levy, Christine; Carpentier, Antoine F.
Afiliación
  • Kourilsky A; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de neurologie, de l'Hôpital Avicenne, 125 route de Stalingrad, 93009, Bobigny, France.
  • Bertrand G; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de radiologie, Hôpital Avicenne, 93009, Bobigny, France.
  • Ursu R; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de neurologie, de l'Hôpital Avicenne, 125 route de Stalingrad, 93009, Bobigny, France.
  • Doridam J; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de neurologie, de l'Hôpital Avicenne, 125 route de Stalingrad, 93009, Bobigny, France.
  • Barlog C; UFR de Santé, Médecine et Biologie Humaine, Université Paris 13, 93009, Bobigny, France.
  • Faillot T; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de neurologie, de l'Hôpital Avicenne, 125 route de Stalingrad, 93009, Bobigny, France.
  • Mandonnet E; UFR de Santé, Médecine et Biologie Humaine, Université Paris 13, 93009, Bobigny, France.
  • Belin C; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de neurochirurgie, Hôpital Beaujon, 92110, Clichy, France.
  • Levy C; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de neurochirurgie, Hôpital Lariboisière, 75010, Paris, France.
  • Carpentier AF; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de neurologie, de l'Hôpital Avicenne, 125 route de Stalingrad, 93009, Bobigny, France.
J Neurol ; 263(3): 524-30, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26754004
Glioblastoma patients often require chronic administration of steroids due to peri-tumoral edema. Preliminary studies showed that treatment with Angiotensin-II Receptor Blockers (ARBs) for high blood pressure might be associated with reduced peri-tumoral edema. In this study, we aim to radiologically assess the effect of ARBs on peri-tumoral edema. We conducted a cross-sectional survey on patients with newly diagnosed GBM. Patients treated with ARBs for high blood pressure were paired to non ARB-treated patients based on similar age, tumor location and tumor size. Patients taking steroids at the time of pre-operative Magnetic Resonance Imaging were excluded from the study. In each pair of patients, we compared the volumes of peri-tumoral hyper T2-Fluid Attenuated Inversion Recovery (FLAIR) signal and the Apparent Diffusion Coefficient (ADC) in the same area. Eleven (11) ARB-treated patients were selected and paired to 11 non ARB-treated controls. Volumes of peri-tumoral hyper T2-FLAIR signal were significantly lower in the ARB-treated group than in the non ARB-treated group (p = 0.02). Additionally, peri-tumoral ADCs were also significantly lower in the treated group (p = 0.02), suggesting that the peri-tumoral area in this group had less edematous features. These results suggest that ARBs may reduce the volume of peri-tumoral hyper T2-FLAIR signal by decreasing edema.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Neoplasias Encefálicas / Glioblastoma / Antagonistas de Receptores de Angiotensina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Neoplasias Encefálicas / Glioblastoma / Antagonistas de Receptores de Angiotensina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania