Your browser doesn't support javascript.
loading
Gray matter integrity within regions of the dorsolateral prefrontal cortical-subcortical network predicts executive function and fine motor dexterity in spina bifida.
Ware, Ashley L; Kulesz, Paulina A; Williams, Victoria J; Juranek, Jenifer; Cirino, Paul T; Fletcher, Jack M.
Afiliación
  • Ware AL; Department of Psychology and Texas Institute for Measurement, Evaluation and Statistics, University of Houston.
  • Kulesz PA; Department of Psychology and Texas Institute for Measurement, Evaluation and Statistics, University of Houston.
  • Williams VJ; Department of Psychology and Texas Institute for Measurement, Evaluation and Statistics, University of Houston.
  • Juranek J; Department of Pediatrics, Children's Learning Institute BRAIN Lab, University of Texas Health Science Center at Houston.
  • Cirino PT; Department of Psychology and Texas Institute for Measurement, Evaluation and Statistics, University of Houston.
  • Fletcher JM; Department of Psychology and Texas Institute for Measurement, Evaluation and Statistics, University of Houston.
Neuropsychology ; 30(4): 492-501, 2016 05.
Article en En | MEDLINE | ID: mdl-26752120
OBJECTIVES: This study examined microstructural properties of cortical and subcortical gray matter components of the dorsolateral prefrontal (DLPFC) cortical-subcortical circuit in relation to parent-rated executive function and fine motor dexterity performance in youth with spina bifida myelomeningocele (SBM). Aberrant gray matter integrity of the DLPFC, basal ganglia nuclei, and thalamus were hypothesized to differentially relate to neurobehavioral outcomes. METHODS: Forty-nine youth between 8 and 18 years (M = 12.34) old with SBM underwent a 3T MRI including diffusion tensor imaging. Neurobehavioral measures of parent-rated executive function and fine motor dexterity were obtained from a standardized neuropsychological evaluation. Relations among indices of gray matter microstructural integrity (mean diffusivity [MD], fractional anisotropy [FA], cortical thickness) and neurobehavior were examined using 3 correlational methods to enhance reliability of brain-behavior relations. RESULTS: In SBM, higher FA values in the caudate were associated with poorer behavioral regulation. Higher FA values in the putamen and greater DLPFC thickness were both associated with poorer fine motor dexterity. CONCLUSION: Behavioral regulation and FA in the caudate related to behavioral inhibition in SBM. Similarly, associations between fine motor dexterity and indices of gray matter integrity in the putamen and DLPFC support fronto-striatal involvement in motor control in SBM. Examination of these neurobehavioral correlates revealed a pattern of attenuated behavioral impairments when gray matter structure was more similar to that of typically developing youth. (PsycINFO Database Record
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disrafia Espinal / Meningomielocele / Corteza Prefrontal / Neostriado / Función Ejecutiva / Sustancia Gris / Inhibición Psicológica / Destreza Motora Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Neuropsychology Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disrafia Espinal / Meningomielocele / Corteza Prefrontal / Neostriado / Función Ejecutiva / Sustancia Gris / Inhibición Psicológica / Destreza Motora Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Neuropsychology Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos