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Are plasma mineral levels related to antibody response to influenza vaccination in older adults?
Kaynar, Ata Murat; Nowalk, Mary Patricia; Lin, Chyongchiou Jeng; Moehling, Krissy K; Susick, Michael; Bakalov, Veli; Pitt, Bruce R; Bain, Daniel J; Ross, Ted M; Saul, Sean G; Raymund, Mahlon; Zimmerman, Richard K.
Afiliación
  • Kaynar AM; a Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Nowalk MP; b Department of Environmental and Occupational Health , University of Pittsburgh Graduate School of Public Health , Pittsburgh , PA , USA.
  • Lin CJ; c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Moehling KK; c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Susick M; c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Bakalov V; c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Pitt BR; d Department of Critical Care Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Bain DJ; d Department of Critical Care Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Ross TM; e Department of Geology and Environmental Science , University of Pittsburgh , Pittsburgh , PA , USA.
  • Saul SG; f Vaccine and Gene Therapy Institute of Florida , Port St. Lucie , FL , USA.
  • Raymund M; c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
  • Zimmerman RK; c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
Hum Vaccin Immunother ; 12(4): 1003-8, 2016 04 02.
Article en En | MEDLINE | ID: mdl-26751915
INTRODUCTION: An effective immune response to vaccination may be related to nutritional status. This study examined the association of plasma mineral levels with hemagglutination inhibition (HI) titers produced in response to influenza vaccine in older adults. METHODS: Prior to (Day 0) and 21 (range = 19-28) days after receiving the 2013-14 influenza vaccine, 109 adults ages 51-81 years, provided blood samples. Serum samples were tested for HI activity against the A/H1N1 and A/H3N2 2013-2014 vaccine virus strains. Plasma minerals were collected in zinc-free tubes and assayed by inductively coupled plasma mass spectrometry. HI titers were reported as seroprotection (≥1:40) and seroconversion (≥ 4-fold rise from Day 0 (minimum HI = 1:10) to Day 21). Both HI titers and mineral values were skewed and thus log2 transformed. Magnesium (Mg), phosphorus (P), zinc (Zn), copper (Cu), iron (Fe), potassium (K) and the Cu to Zn ratio were tested. Logistic regression analyses were used to determine the associations between mineral levels and seroconversion and seroprotection of HI titers for each influenza A strain. RESULTS: Participants were 61% white, 28% male, 39% diabetic, and 81% overweight/obese with a mean age of 62.6 y. In logistic regression, Day 21 A/H1N1 seroprotection was associated with P and Zn at Day 21(P < 0.05). Seroconversion of A/H1N1 was associated with Day 21 Cu, P, and Mg (P < 0.03). Day 21 A/H3N2 seroprotection and seroconversion were associated with Day 21 P (P < 0.05). CONCLUSIONS: Phosphorus was associated with seroprotection and seroconversion to influenza A after vaccination; these associations warrant additional studies with larger, more diverse population groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Seroconversión / Minerales / Anticuerpos Antivirales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Vaccin Immunother Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Seroconversión / Minerales / Anticuerpos Antivirales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Vaccin Immunother Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos