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Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.
Demont, Emmanuel H; Bailey, James M; Bit, Rino A; Brown, Jack A; Campbell, Colin A; Deeks, Nigel; Dowell, Simon J; Eldred, Colin; Gaskin, Pam; Gray, James R J; Haynes, Andrea; Hirst, David J; Holmes, Duncan S; Kumar, Umesh; Morse, Mary A; Osborne, Greg J; Renaux, Jessica F; Seal, Gail A L; Smethurst, Chris A; Taylor, Simon; Watson, Robert; Willis, Robert; Witherington, Jason.
Afiliación
  • Demont EH; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Bailey JM; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Bit RA; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Brown JA; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Campbell CA; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Deeks N; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Dowell SJ; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Eldred C; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Gaskin P; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Gray JR; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Haynes A; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Hirst DJ; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Holmes DS; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Kumar U; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Morse MA; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Osborne GJ; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Renaux JF; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Seal GA; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Smethurst CA; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Taylor S; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Watson R; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Willis R; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
  • Witherington J; Immuno Inflammation Therapeutic Area Unit, and ‡Platform Technology and Science, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
J Med Chem ; 59(3): 1003-20, 2016 Feb 11.
Article en En | MEDLINE | ID: mdl-26751273
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / Receptores de Lisoesfingolípidos / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / Receptores de Lisoesfingolípidos / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos