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Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation.
Dominguez-Medina, Sergio; Kisley, Lydia; Tauzin, Lawrence J; Hoggard, Anneli; Shuang, Bo; Indrasekara, A Swarnapali D S; Chen, Sishan; Wang, Lin-Yung; Derry, Paul J; Liopo, Anton; Zubarev, Eugene R; Landes, Christy F; Link, Stephan.
Afiliación
  • Dominguez-Medina S; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Kisley L; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Tauzin LJ; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Hoggard A; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Shuang B; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Indrasekara AS; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Chen S; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Wang LY; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Derry PJ; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Liopo A; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Zubarev ER; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
  • Landes CF; Department of Materials Science and NanoEngineering, Rice University , Houston, Texas 77251, United States.
  • Link S; Department of Chemistry, Rice University , Houston, Texas 77251, United States.
ACS Nano ; 10(2): 2103-12, 2016 Feb 23.
Article en En | MEDLINE | ID: mdl-26751094
The response of living systems to nanoparticles is thought to depend on the protein corona, which forms shortly after exposure to physiological fluids and which is linked to a wide array of pathophysiologies. A mechanistic understanding of the dynamic interaction between proteins and nanoparticles and thus the biological fate of nanoparticles and associated proteins is, however, often missing mainly due to the inadequacies in current ensemble experimental approaches. Through the application of a variety of single molecule and single particle spectroscopic techniques in combination with ensemble level characterization tools, we identified different interaction pathways between gold nanorods and bovine serum albumin depending on the protein concentration. Overall, we found that local changes in protein concentration influence everything from cancer cell uptake to nanoparticle stability and even protein secondary structure. We envision that our findings and methods will lead to strategies to control the associated pathophysiology of nanoparticle exposure in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanotubos / Nanopartículas del Metal / Desplegamiento Proteico / Corona de Proteínas / Oro Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: ACS Nano Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanotubos / Nanopartículas del Metal / Desplegamiento Proteico / Corona de Proteínas / Oro Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: ACS Nano Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos