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Aberrant small airways function relates to asthma severity in young children.
Kalliola, Satu; Malmberg, L Pekka; Pelkonen, Anna S; Mäkelä, Mika J.
Afiliación
  • Kalliola S; Department of Allergology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland. Electronic address: satu.kalliola@hus.fi.
  • Malmberg LP; Department of Allergology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.
  • Pelkonen AS; Department of Allergology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.
  • Mäkelä MJ; Department of Allergology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.
Respir Med ; 111: 16-20, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26733229
BACKGROUND: Frequency dependence of resistance (R5-20) assessed by impulse oscillometry (IOS) is suggested to be a measure of small airways. Small airways involvement during induced bronchoconstriction has been shown to reflect severity of asthma in adults. OBJECTIVE: Our aim was to evaluate if methacholine (Mch) induced changes in R5-20 are associated with the severity of exercise induced bronchoconstriction (EIB) in young children. METHODS: A total of 109 children aged 3-8 years were studied, 95 with obstructive symptoms and 14 in good health, to assess small airways function during a Mch challenge. R5-20 and other IOS resistance and reactance parameters were measured at baseline and after the Mch challenge. In a standardized exercise test, the children were grouped according to the severity of EIB expressed as the percentage increase in resistance at 5 Hz (ΔR5) after exercise, indicating either no EIB (ΔR5 < 40%, n = 84), moderate EIB (ΔR5 40-80%, n = 13) and severe EIB (ΔR5 > 80%, n = 12). RESULTS: The baseline R5-20 was not associated with the severity of EIB, but during Mch induced bronchoconstriction the change in R5-20 was significantly higher in children with severe EIB (2.61 fold increase) than in children with moderate EIB (1.48) or no EIB (1.74, p = 0.036). No significant associations were found in changes of other IOS parameters. The children with severe EIB also used more short-acting beta-agonists during the past two months than the other two groups (p < 0.001). CONCLUSION: Frequency dependence of resistance (R5-20) measured by IOS during the Mch induced bronchoconstriction and more frequent use of beta-agonists are associated with severe EIB in young children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad Respiratoria / Asma Inducida por Ejercicio / Remodelación de las Vías Aéreas (Respiratorias) Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Respir Med Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad Respiratoria / Asma Inducida por Ejercicio / Remodelación de las Vías Aéreas (Respiratorias) Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Respir Med Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido