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Studies of Tumor Suppressor Genes via Chromosome Engineering.
Kugoh, Hiroyuki; Ohira, Takahito; Oshimura, Mitsuo.
Afiliación
  • Kugoh H; Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan. kugoh@med.tottori-u.ac.jp.
  • Ohira T; Chromosome Engineering Research Center (CERC), Tottori University, Yonago, Tottori 683-8503, Japan. kugoh@med.tottori-u.ac.jp.
  • Oshimura M; Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan. ohira@med.tottori-u.ac.jp.
Cancers (Basel) ; 8(1)2015 Dec 30.
Article en En | MEDLINE | ID: mdl-26729168
The development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related genes plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technology based on microcell-mediated chromosome transfer (MMCT) is an effective approach for identification of tumor suppressor genes. The studies have revealed at least five tumor suppression effects. The discovery of novel tumor suppressor genes provide greater understanding of the complex signaling pathways that underlie the development and progression of malignant tumors. These advances are being exploited to develop targeted drugs and new biological therapies for cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza