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The Role of Neoadjuvant Chemotherapy in the Treatment of Nasopharyngeal Carcinoma: A Multi-institutional Retrospective Study (KROG 11-06) Using Propensity Score Matching Analysis.
Song, Jin Ho; Wu, Hong-Gyun; Keam, Bhum Suk; Hah, Jeong Hun; Ahn, Yong Chan; Oh, Dongryul; Noh, Jae Myoung; Park, Hyo Jung; Lee, Chang Geol; Keum, Ki Chang; Cha, Jihye; Cho, Kwan Ho; Moon, Sung Ho; Kim, Ji-Yoon; Chung, Woong-Ki; Oh, Young Taek; Kim, Won Taek; Cho, Moon-June; Kay, Chul Seung; Kim, Yeon-Sil.
Afiliación
  • Song JH; Department of Radiation Oncology, Gyeongsang National University Hospital and Gyeongsang National University School of Medicine, Jinju, Korea.
  • Wu HG; Department of Radiation Oncology, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Keam BS; Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Hah JH; Department of Otolaryngology-Head and Neck Surgery, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Ahn YC; Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Oh D; Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Noh JM; Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Park HJ; Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Lee CG; Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
  • Keum KC; Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
  • Cha J; Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
  • Cho KH; Department of Radiation Oncology, Research Institute and Hospital, National Cancer Center, Seoul, Korea.
  • Moon SH; Department of Radiation Oncology, Research Institute and Hospital, National Cancer Center, Seoul, Korea.
  • Kim JY; Department of Radiation Oncology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • Chung WK; Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Korea.
  • Oh YT; Department of Radiation Oncology, Ajou University School of Medicine, Suwon, Korea.
  • Kim WT; Department of Radiation Oncology, Pusan National University School of Medicine, Busan, Korea.
  • Cho MJ; Department of Radiation Oncology, Chungnam National University School of Medicine, Daejeon, Korea.
  • Kay CS; Department of Radiation Oncology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
  • Kim YS; Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Cancer Res Treat ; 48(3): 917-27, 2016 Jul.
Article en En | MEDLINE | ID: mdl-26727716
PURPOSE: We compared the treatment results and toxicity in nasopharyngeal carcinoma (NPC) patients treated with concurrent chemotherapy (CCRT) alone (the CRT arm) or neoadjuvant chemotherapy followed by CCRT (the NCT arm). MATERIALS AND METHODS: A multi-institutional retrospective study was conducted to review NPC patterns of care and treatment outcome. Data of 568 NPC patients treated by CCRT alone or by neoadjuvant chemotherapy followed by CCRT were collected from 15 institutions. Patients in both treatment arms were matched using the propensity score matching method, and the clinical outcomes were analyzed. RESULTS: After matching, 300 patients (150 patients in each group) were selected for analysis. Higher 5-year locoregional failure-free survival was observed in the CRT arm (85% vs. 72%, p=0.014). No significant differences in distant failure-free survival (DFFS), disease-free survival (DFS), and overall survival were observed between groups. In subgroup analysis, the NCT arm showed superior DFFS and DFS in stage IV patients younger than 60 years. No significant difference in compliance and toxicity was observed between groups, except the radiation therapy duration was slightly shorter in the CRT arm (50.0 days vs. 53.9 days, p=0.018). CONCLUSION: This study did not show the superiority of NCT followed by CCRT over CCRT alone. Because NCT could increase the risk of locoregional recurrences, it can only be considered in selected young patients with advanced stage IV disease. The role of NCT remains to be defined and should not be viewed as the standard of care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Nasofaríngeas / Terapia Neoadyuvante / Quimioradioterapia / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Treat Año: 2016 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Nasofaríngeas / Terapia Neoadyuvante / Quimioradioterapia / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Treat Año: 2016 Tipo del documento: Article Pais de publicación: Corea del Sur