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[Receptor tyrosine kinase KIT may regulate expression of genes involved in spontaneous regression of neuroblastoma].
Lebedev, T D; Spirin, P V; Suntsova, M V; Ivanova, A V; Buzdin, A A; Prokofjeva, M M; Rubtsov, P M; Prassolov, V S.
Afiliación
  • Lebedev TD; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia;
  • Spirin PV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia;
  • Suntsova MV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.
  • Ivanova AV; Rogachev Federal Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, 117997 Russia.
  • Buzdin AA; First Oncology Research and Advisory Center, Moscow, 117198 Russia.
  • Prokofjeva MM; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia;
  • Rubtsov PM; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia;
  • Prassolov VS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia;
Mol Biol (Mosk) ; 49(6): 1052-5, 2015.
Article en Ru | MEDLINE | ID: mdl-26710790
Hallmark of neuroblastoma is an ability of this malignant tumor to undergo spontaneous regression or differentiation into benign tumor during any stage of the disease, but it is little known about mechanisms of these phenomena. We studied effect of receptor tyrosine kinase receptor KIT on expression of genes, which may be involved in tumor spontaneous regression. Downregulation of KIT expression by RNA interference in SH-SY5Y cells causes suppression of neurotrophin receptor NGFR expression that may promote the loss of sensibility of cells to nerve growth factors, also it causes upregulation of TrkA receptor expression which can stimulate cell differentiation or apoptosis in NGF dependent manner. Furthermore there is an upregulation of genes which stimulate malignant cell detection by immune system, such as genes of major histocompatibility complex HLA class I HLA-B and HLA-C, and interferon-γ receptors IFNGR1 and IFNGR2 genes. Thus KIT can mediate neuroblastoma cell sensibility to neurotrophins and immune system components--two factors directly contributing to spontaneous regression of neuroblastoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Proteínas Proto-Oncogénicas c-kit / Regresión Neoplásica Espontánea / Neuroblastoma Límite: Humans Idioma: Ru Revista: Mol Biol (Mosk) Año: 2015 Tipo del documento: Article Pais de publicación: Rusia
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Proteínas Proto-Oncogénicas c-kit / Regresión Neoplásica Espontánea / Neuroblastoma Límite: Humans Idioma: Ru Revista: Mol Biol (Mosk) Año: 2015 Tipo del documento: Article Pais de publicación: Rusia