Enhancing adoptive T cell immunotherapy with microRNA therapeutics.

Ji, Yun; Hocker, James D; Gattinoni, Luca

Ji, Yun; Hocker, James D; Gattinoni, Luca.

Afiliación

Ji Y; Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA. Electronic address: jiyun@mail.nih.gov.
Hocker JD; Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA.
Gattinoni L; Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA. Electronic address: gattinol@mail.nih.gov.

Semin Immunol ; 28(1): 45-53, 2016 02.

Article en En | MEDLINE | ID: mdl-26710685

RESUMEN

Adoptive T cell-based immunotherapies can mediate complete and durable regressions in patients with advanced cancer, but current response rates remain inadequate. Maneuvers to improve the fitness and antitumor efficacy of transferred T cells have been under extensive exploration in the field. Small non-coding microRNAs have emerged as critical modulators of immune system homeostasis and T cell immunity. Here, we summarize recent advances in our understanding of the role of microRNAs in regulating T cell activation, differentiation, and function. We also discuss how microRNA therapeutics could be employed to fine-tune T cell receptor signaling and enhance T cell persistence and effector functions, paving the way for the next generation of adoptive immunotherapies.

Asunto(s)

Vacunas contra el Cáncer/inmunología; Inmunoterapia Adoptiva/métodos; MicroARNs/genética; Neoplasias/terapia; ARN Pequeño no Traducido/genética; Receptores de Antígenos de Linfocitos T/metabolismo; Linfocitos T/fisiología; Animales; Diferenciación Celular/genética; Supervivencia Celular; Citotoxicidad Inmunológica; Humanos; Inmunidad Celular/genética; Activación de Linfocitos/genética; MicroARNs/inmunología; Neoplasias/inmunología; ARN Pequeño no Traducido/inmunología; Receptores de Antígenos de Linfocitos T/genética; Transducción de Señal; Linfocitos T/trasplante

Palabras clave

Adoptive cell transfer; CD8(+) T cells; Microrna (miRNA); T cell differentiation; Tumor immunotherapy

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Linfocitos T / Inmunoterapia Adoptiva / Vacunas contra el Cáncer / MicroARNs / ARN Pequeño no Traducido / Neoplasias Límite: Animals / Humans Idioma: En Revista: Semin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google