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Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance.
Cattaneo, G; Schumacher, M; Maurer, C; Wolfertz, J; Jost, T; Büchert, M; Keuler, A; Boos, L; Shah, M J; Foerster, K; Niesen, W-D; Ihorst, G; Urbach, H; Meckel, S.
Afiliación
  • Cattaneo G; From Acandis (G.C., J.W., T.J., M.B.), Pforzheim, Germany.
  • Schumacher M; Departments of Neuroradiology (M.S., C.M., A.K., L.B., H.U., S.M.).
  • Maurer C; Departments of Neuroradiology (M.S., C.M., A.K., L.B., H.U., S.M.).
  • Wolfertz J; From Acandis (G.C., J.W., T.J., M.B.), Pforzheim, Germany.
  • Jost T; From Acandis (G.C., J.W., T.J., M.B.), Pforzheim, Germany.
  • Büchert M; From Acandis (G.C., J.W., T.J., M.B.), Pforzheim, Germany.
  • Keuler A; Departments of Neuroradiology (M.S., C.M., A.K., L.B., H.U., S.M.).
  • Boos L; Departments of Neuroradiology (M.S., C.M., A.K., L.B., H.U., S.M.).
  • Shah MJ; Neurosurgery (M.J.S.).
  • Foerster K; University Heart Center (K.F.).
  • Niesen WD; Neurology (W.-D.N.).
  • Ihorst G; University Study Center (G.I.), University Hospital Freiburg, Freiburg, Germany.
  • Urbach H; Departments of Neuroradiology (M.S., C.M., A.K., L.B., H.U., S.M.).
  • Meckel S; Departments of Neuroradiology (M.S., C.M., A.K., L.B., H.U., S.M.) stephanmeckel@gmail.com.
AJNR Am J Neuroradiol ; 37(5): 885-91, 2016 May.
Article en En | MEDLINE | ID: mdl-26705319
BACKGROUND AND PURPOSE: Therapeutic hypothermia represents a promising neuroprotective treatment in acute ischemic stroke. Selective cerebral hypothermia applied early, prior to and during endovascular mechanical recanalization therapy, may be beneficial in the critical phase of reperfusion. We aimed to assess the feasibility of a new intracarotid cooling catheter in an animal model. MATERIALS AND METHODS: Nine adult sheep were included. Temperature probes were introduced into the frontal and temporal brain cortices bilaterally. The cooling catheter system was introduced into a common carotid artery. Selective blood cooling was applied for 180 minutes. Systemic and local brain temperatures were measured during cooling and rewarming. Common carotid artery diameters and flow were measured angiographically and by Doppler sonography. RESULTS: The common carotid artery diameter was between 6.7 and 7.3 mm. Common carotid artery blood flow velocities increased moderately during cooling and after catheter removal. Maximum cerebral cooling in the ipsilateral temporal cortex was -4.7°C (95% CI, -5.1 to -4.0°C). Ipsilateral brain temperatures dropped significantly faster and became lower compared with the contralateral cortex with maximum temperature difference of -1.3°C (95% CI, -1.5 to -1.0°C; P < .0001) and compared with systemic temperature (-1.4°C; 95% CI, -1.7 to -1.0°C; P < .0001). CONCLUSIONS: Sheep proved a feasible animal model for the intracarotid cooling catheter. Fast induction of selective mild hypothermia was achieved within the cooled cerebral hemisphere, with stable temperature gradients in the contralateral brain and systemic blood. Further studies are required to demonstrate any therapeutic benefit of selective cerebral cooling in a stroke model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Arteria Carótida Común / Hipotermia Inducida Límite: Animals Idioma: En Revista: AJNR Am J Neuroradiol Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Arteria Carótida Común / Hipotermia Inducida Límite: Animals Idioma: En Revista: AJNR Am J Neuroradiol Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos