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Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis.
Prochazka, Jan; Prochazkova, Michaela; Du, Wen; Spoutil, Frantisek; Tureckova, Jolana; Hoch, Renee; Shimogori, Tomomi; Sedlacek, Radislav; Rubenstein, John L; Wittmann, Torsten; Klein, Ophir D.
Afiliación
  • Prochazka J; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
  • Prochazkova M; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
  • Du W; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
  • Spoutil F; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
  • Tureckova J; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
  • Hoch R; Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, 1500 4th Street, San Francisco, CA 94143, USA.
  • Shimogori T; Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, 2-1 Hirosawa Wako, Saitama 351-0198, Japan.
  • Sedlacek R; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
  • Rubenstein JL; Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, 1500 4th Street, San Francisco, CA 94143, USA.
  • Wittmann T; Department of Cell and Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
  • Klein OD; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, San Francisco,
Dev Cell ; 35(6): 713-24, 2015 Dec 21.
Article en En | MEDLINE | ID: mdl-26702830
The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diente / Movimiento Celular / Regulación del Desarrollo de la Expresión Génica / Diente Molar / Morfogénesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diente / Movimiento Celular / Regulación del Desarrollo de la Expresión Génica / Diente Molar / Morfogénesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos