Your browser doesn't support javascript.
loading
Pre-transplant wasting (as measured by muscle index) is a novel prognostic indicator in lung transplantation.
Kelm, Diana J; Bonnes, Sara L; Jensen, Michael D; Eiken, Patrick W; Hathcock, Matthew A; Kremers, Walter K; Kennedy, Cassie C.
Afiliación
  • Kelm DJ; Division of Pulmonary Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Bonnes SL; Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Jensen MD; Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Eiken PW; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Hathcock MA; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Kremers WK; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Kennedy CC; William J. Von Liebig Transplant Center, Mayo Clinic, Rochester, MN, USA.
Clin Transplant ; 30(3): 247-55, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26701203
BACKGROUND: Frailty in non-transplant populations increases morbidity and mortality. Muscle wasting is an important frailty characteristic. Low body mass index is used to measure wasting, but can over- or underestimate muscle mass. Computed tomography (CT) software can directly measure muscle mass. It is unknown if muscle wasting is important in lung transplantation. AIM AND METHODS: The aim of this single-center, retrospective cohort study was to determine whether pre-transplant low muscle mass (as measured by CT using Slice-O-matic software at L2-L3 interspace) was associated with post-transplantation mortality, hospital and intensive care unit length of stay (LOS), duration of mechanical ventilation, or primary graft dysfunction. Lung transplant recipients from 2000 to 2012 with a CT scan less than six months prior to transplant were included. Univariate, multivariate, and Kaplan-Meier analyses were conducted. RESULTS: Thirty-six patients were included. Those with low muscle index (lower 25th percentile) had a worse survival (hazard ratio = 3.83; 95% confidence interval 1.42-10.3; p = 0.007) and longer hospital LOS by an estimated 7.2 d (p = 0.01) when adjusted for age and sex as compared to those with higher muscle index. CONCLUSION: Low muscle index at lung transplantation is associated with worse survival and increased hospital LOS.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Atrofia Muscular / Trasplante de Pulmón / Disfunción Primaria del Injerto / Rechazo de Injerto / Enfermedades Pulmonares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transplant Asunto de la revista: TRANSPLANTE Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Atrofia Muscular / Trasplante de Pulmón / Disfunción Primaria del Injerto / Rechazo de Injerto / Enfermedades Pulmonares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transplant Asunto de la revista: TRANSPLANTE Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca