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Toward understanding the selective anticancer capacity of cold atmospheric plasma--a model based on aquaporins (Review).
Yan, Dayun; Talbot, Annie; Nourmohammadi, Niki; Sherman, Jonathan H; Cheng, Xiaoqian; Keidar, Michael.
Afiliación
  • Yan D; Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052.
  • Talbot A; Columbian College of Arts and Sciences, The George Washington University, Phillips Hall, 801 22nd Street, NW, Suite 212, Washington, DC 20052.
  • Nourmohammadi N; Department of Biological Sciences, The George Washington University, Lisner Hall, 2023 G Street, NW, Suite 340, Washington, DC 20052.
  • Sherman JH; Neurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street, NW, 7th Floor, Washington, DC 20037.
  • Cheng X; Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052.
  • Keidar M; Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052.
Biointerphases ; 10(4): 040801, 2015 Dec 22.
Article en En | MEDLINE | ID: mdl-26700469
Selectively treating tumor cells is the ongoing challenge of modern cancer therapy. Recently, cold atmospheric plasma (CAP), a near room-temperature ionized gas, has been demonstrated to exhibit selective anticancer behavior. However, the mechanism governing such selectivity is still largely unknown. In this review, the authors first summarize the progress that has been made applying CAP as a selective tool for cancer treatment. Then, the key role of aquaporins in the H2O2 transmembrane diffusion is discussed. Finally, a novel model, based on the expression of aquaporins, is proposed to explain why cancer cells respond to CAP treatment with a greater rise in reactive oxygen species than homologous normal cells. Cancer cells tend to express more aquaporins on their cytoplasmic membranes, which may cause the H2O2 uptake speed in cancer cells to be faster than in normal cells. As a result, CAP treatment kills cancer cells more easily than normal cells. Our preliminary observations indicated that glioblastoma cells consumed H2O2 much faster than did astrocytes in either the CAP-treated or H2O2-rich media, which supported the selective model based on aquaporins.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acuaporinas / Gases em Plasma / Presión Hidrostática / Modelos Biológicos / Antineoplásicos Límite: Humans Idioma: En Revista: Biointerphases Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acuaporinas / Gases em Plasma / Presión Hidrostática / Modelos Biológicos / Antineoplásicos Límite: Humans Idioma: En Revista: Biointerphases Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos