The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.

Ho, Tina; Watt, Brenda; Spruce, Lynn A; Seeholzer, Steven H; Marks, Michael S

Ho, Tina; Watt, Brenda; Spruce, Lynn A; Seeholzer, Steven H; Marks, Michael S.

Afiliación

Ho T; From the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 and the Cell and Molecular Biology Graduate Group, the Department of Pathology and Laboratory Medicine, and.
Watt B; From the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 and the Cell and Molecular Biology Graduate Group, the Department of Pathology and Laboratory Medicine, and.
Spruce LA; From the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 and.
Seeholzer SH; From the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 and.
Marks MS; From the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 and the Cell and Molecular Biology Graduate Group, the Department of Pathology and Laboratory Medicine, and the Department of Physiology, University of Pennsylvania, Philad

J Biol Chem ; 291(7): 3595-612, 2016 Feb 12.

Article en En | MEDLINE | ID: mdl-26694611

Asunto(s)

Amiloide/química; Modelos Moleculares; Cuerpos Multivesiculares/ultraestructura; Procesamiento Proteico-Postraduccional; Antígeno gp100 del Melanoma/química; Sustitución de Aminoácidos; Amiloide/metabolismo; Amiloide/ultraestructura; Línea Celular Tumoral; Cisteína/química; Cisteína/metabolismo; Cistina/química; Cistina/metabolismo; Dimerización; Retículo Endoplásmico/enzimología; Retículo Endoplásmico/metabolismo; Retículo Endoplásmico/ultraestructura; Aparato de Golgi/enzimología; Aparato de Golgi/metabolismo; Aparato de Golgi/ultraestructura; Proteínas Fluorescentes Verdes/química; Proteínas Fluorescentes Verdes/genética; Proteínas Fluorescentes Verdes/metabolismo; Humanos; Kringles; Microscopía Electrónica de Transmisión; Peso Molecular; Cuerpos Multivesiculares/química; Cuerpos Multivesiculares/metabolismo; Mutagénesis Sitio-Dirigida; Mutación Puntual; Pliegue de Proteína; Estabilidad Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Antígeno gp100 del Melanoma/genética; Antígeno gp100 del Melanoma/metabolismo

Palabras clave

Pmel17; cysteine-mediated cross-linking; disulfide; endosome; fibril; melanogenesis; melanosome; membrane trafficking; oxidation-reduction (redox); protein aggregation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Moleculares / Procesamiento Proteico-Postraduccional / Cuerpos Multivesiculares / Antígeno gp100 del Melanoma / Amiloide Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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