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Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.
Jeon, Hui-Jeon; Choi, Hyeon-Son; Lee, Yeon-Joo; Hwang, Ji-Hyun; Lee, Ok-Hwan; Seo, Min-Jung; Kim, Kui-Jin; Lee, Boo-Yong.
Afiliación
  • Jeon HJ; Department of Food Science and Biotechnology, CHA University, Seongnam, Gyeonggi 463-400, Korea. jhj_0324@naver.com.
  • Choi HS; Department of Food Science and Technology, Seoul Women's University, Hwarang, Nowon, Seoul 139-774, Korea. hschoi@swu.ac.kr.
  • Lee YJ; Department of Food Science and Biotechnology, CHA University, Seongnam, Gyeonggi 463-400, Korea. eyeonjoo@gmail.com.
  • Hwang JH; Department of Food Science and Biotechnology, CHA University, Seongnam, Gyeonggi 463-400, Korea. hwangjh0947@gmail.com.
  • Lee OH; Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. loh99@kangwon.ac.kr.
  • Seo MJ; Department of Food Science and Biotechnology, CHA University, Seongnam, Gyeonggi 463-400, Korea. mjseo@kirams.re.kr.
  • Kim KJ; Department of Food Science and Biotechnology, CHA University, Seongnam, Gyeonggi 463-400, Korea. Kuijin.Kim@gmail.com.
  • Lee BY; Department of Food Science and Biotechnology, CHA University, Seongnam, Gyeonggi 463-400, Korea. bylee@cha.ac.kr.
Molecules ; 20(12): 21715-31, 2015 Dec 04.
Article en En | MEDLINE | ID: mdl-26690099
Seapolynol (SN) is a polyphenol mixture derived from Ecklonia cava. We evaluated the effects of SN on lipid accumulation in adipocytes, zebrafish, and mice. SN effectively inhibited lipid accumulation in three experimental models by suppressing adipogenic factors. Triglyceride synthetic enzymes such as diacylglycerol acyltransferase 1 (DGAT1) and GPAT3 were also downregulated by SN. This SN-induced inhibition of adipogenic factors was shown to be due to the regulatory effect of SN on early adipogenic factors; SN downregulated the expression of Krueppel-like factor 4 (KLF4), KLF5, CCAAT-enhancer-binding protein ß (C/EBPß), C/EBPδ, and Protein C-ets-2 (ETS2), while KLF2, an anti-early adipogenic factor, was upregulated by SN. SN-mediated inhibition in early adipogenesis was closely correlated with the inhibition of mitotic clonal expansion via cell cycle arrest. SN inhibited cell cycle progression by suppressing cell cycle regulators, such as cyclin A, cyclinD, and pRb but increased p27, a cell cycle inhibitor. In a mouse study, SN effectively reduced body weight and plasma lipid increases induced by a high-fat diet; triglycerides, total cholesterol, and low-density lipoprotein (LDL) levels were markedly reduced by SN. Moreover, SN remarkably improved high-fat-diet-induced hepatic lipid accumulation. Furthermore, SN activated AMP-activated protein kinase-α (AMPKα), an energy sensor, to suppress acetyl-coA carboxylase (ACC), inhibiting lipid synthesis. Our study suggests that SN may be an edible agent that can play a positive role in prevention of metabolic disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Adipocitos / Fármacos Antiobesidad / Metabolismo de los Lípidos / Polifenoles Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Adipocitos / Fármacos Antiobesidad / Metabolismo de los Lípidos / Polifenoles Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Suiza