Enhanced Ehrlich tumor inhibition using DOX-NP and gold nanoparticles loaded liposomes.

Mady, Mohsen Mahmoud; Al-Shaikh, Fatima Hasan; Al-Farhan, Faridah Farhan; Aly, Amany Abdullah; Al-Mohanna, Mai Abdullah; Ghannam, Magdy Mohammed

Mady, Mohsen Mahmoud; Al-Shaikh, Fatima Hasan; Al-Farhan, Faridah Farhan; Aly, Amany Abdullah; Al-Mohanna, Mai Abdullah; Ghannam, Magdy Mohammed.

Afiliación

Mady MM; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia / Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
Al-Shaikh FH; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.
Al-Farhan FF; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.
Aly AA; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia / Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
Al-Mohanna MA; King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Ghannam MM; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia / Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.

Pak J Pharm Sci ; 28(6 Suppl): 2321-5, 2015 Nov.

Article en En | MEDLINE | ID: mdl-26687750

RESUMEN

Treatment with doxorubicin (DOX) is a common treatment for different types of cancer. DOX-NP is one of a well established marketed liposomal formulation for DOX. It has advantages over free DOX in reducing the cardiac toxicity and increasing the efficacy. Gold nanoparticles (GNPs), have been widely used in biomedical applications such as medical imaging and biosensors. Mice bearing Ehrlich tumor were injected with saline, free doxorubicin (DOX) in solution, gold nanoparticles loaded liposomes and commercial liposomal encapsulated doxorubicin (DOX-NP). The results showed that GNPs loaded liposomes could enhance the antitumor activity of commercial liposomal formulation (DOX-NP) and displayed significantly decreased systemic toxicity compared with free DOX and commercial liposomal formulation (DOX-NP) at the equivalent dose. So the injection of GNPs and DOX-NP is expected to increase the cell killing and make it a promising approach to cancer treatment.

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Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Pakistán

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